Handcuffs for bacteria – NDP52 orchestrates xenophagy of intracellular Salmonella

Authors:

Pauline Verlhac1,2,3,4,5, Christophe Viret1,2,3,4,5 and Mathias Faure1,2,3,4,5

doi: 10.15698/mic2015.06.208
Volume 2, pp. 214 to 215, published 21/05/2015.

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Affiliations:

1 CIRI, International Center for Infectiology Research, Université de Lyon, 69007 Lyon, France.

2 Inserm, U1111, 69007 Lyon, France.

3 CNRS, UMR5308, 69007 Lyon, France.

4 Ecole Normale Supérieure de Lyon, 69007 Lyon, France.

5 Université Lyon 1, Centre International de Recherche en Infectiologie, 69007 Lyon, France.

Keywords: 

autophagy, xenophagy, NDP52, bacteria

Corresponding Author(s):

Mathias Faure, CIRI, INSERM U1111, CNRS UMR 5308, ENL-L, UCBL1 - 21, Avenue Tony Garnier; 69365 Lyon Cedex 07, France mathias.faure@inserm.fr

Conflict of interest statement:

The authors have no conflict of interest.

Please cite this article as:

Pauline Verlhac, Christophe Viret and Mathias Faure (2015). Handcuffs for Bacteria - NDP52 orchestrates xenophagy of intracellular Salmonella. Microbial Cell 2(6): 214-215.

© 2015 Verlhac et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.

Abstract:

Eukaryotic cells can selectively target and degrade intracellular pathogens using autophagy, a process referred to as xenophagy. This selectivity is controlled by proteins called autophagy receptors, which can recognise pathogens and address them to the autophagy machinery. Among them, NDP52 can recognise Salmonella Typhimurium on the one hand and the ATG8 family member LC3C on the other hand, thus allowing the docking of the bacteria to a growing autophagosome. Additionally, we recently reported that NDP52 is involved in the maturation of the bacteria-containing autophagosome and hence necessary for the ultimate degradation of the bacteria. These two functions of NDP52 are independent as they rely on distinct binding domains and protein partners. Therefore, NDP52 plays a dual role during xenophagy, first by targeting the bacteria to the autophagy machinery and then by regulating its degradation.