Integrative metabolomics as emerging tool to study autophagy regulation

Authors:

Sarah Stryeck1, Ruth Birner-Gruenberger2, Tobias Madl1,*

doi: 10.15698/mic2017.08.584
Volume 4, pp. 240 to 258, published 13/07/2017.

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Affiliations:

1 Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, 8010 Graz, Austria.

2 Research Unit for Functional Proteomics and Metabolic Pathways, Institute of Pathology, Medical University of Graz, 8010 Graz, Austria.

Keywords: 

metabolomics, autophagy, metabolites, aging, nuclear magnetic resonance, mass spectrometry.

Corresponding Author(s):

Assoc. Univ.-Prof. Dr. Tobias Madl, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstrasse 6/6, A-8010 Graz, Austria; Tel: +43 316 385 71972; Fax: +43 316 385 79615; tobias.madl@medunigraz.at

Conflict of interest statement:

The authors declare no conflict of interest.

Please cite this article as:

Sarah Stryeck, Ruth Birner-Gruenberger, Tobias Madl (2017). Integrative metabolomics as emerging tool to study autophagy regulation. Microbial Cell 4(8): 240-258. doi: 10.15698/mic2017.08.584

© 2017 Stryeck et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.

Abstract:

Recent technological developments in metabolomics research have enabled in-depth characterization of complex metabolite mixtures in a wide range of biological, biomedical, environmental, agricultural, and nutritional research fields. Nuclear magnetic resonance spectroscopy and mass spectrometry are the two main platforms for performing metabolomics studies. Given their broad applicability and the systemic insight into metabolism that can be obtained it is not surprising that metabolomics becomes increasingly popular in basic biological research. In this review, we provide an overview on key metabolites, recent studies, and future opportunities for metabolomics in studying autophagy regulation. Metabolites play a pivotal role in autophagy regulation and are therefore key targets for autophagy research. Given the recent success of metabolomics, it can be expected that metabolomics approaches will contribute significantly to deciphering the complex regulatory mechanisms involved in autophagy in the near future and promote understanding of autophagy and autophagy-related diseases in living cells and organisms.