Live fast, die soon: cell cycle progression and lifespan in yeast cells
Authors:Javier Jiménez, Samuel Bru, Mariana PC Ribeiro and Josep Clotet
doi: 10.15698/mic2015.03.191
Volume 2, pp. 62 to 67, published 02/03/2015.
Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.
Keywords:
cell cycle, lifespan, phosphate, Pho85
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Javier Jiménez, Samuel Bru, Mariana PC Ribeiro and Josep Clotet (2015). Live fast, die soon: cell cycle progression and lifespan in yeast cells. Microbial Cell 2(3): 62-67.
© 2015 Jiménez et al.. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Our understanding of lifespan has benefited enormously from the study of a simple model, the yeast Saccharomyces cerevisiae. Although a unicellular organism, yeasts undergo many of the processes directly related with aging that to some extent are conserved in mammalian cells. Nutrient-limiting conditions have been involved in lifespan extension, especially in the case of caloric restriction, which also has a direct impact on cell cycle progression. In fact, other environmental stresses (osmotic, oxidative) that interfere with normal cell cycle progression also influence the lifespan of cells, indicating a relationship between lifespan and cell cycle control. In the present review we compile and discuss new findings related to how cell cycle progression is regulated by other nutrients. We centred this review on the analysis of phosphate, also give some attention to nitrogen, and the impact of these nutrients on lifespan.