Mitochondrial regulation of cell death: a phylogenetically conserved control
Authors:Lorenzo Galluzzi1,2,3,4,5, Oliver Kepp1,2,3,4,6 and Guido Kroemer1,2,3,4,6,7,8
doi: 10.15698/mic2016.03.483
Volume 3, pp. 101 to 108, published 23/02/2016.
1 Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.
2 INSERM, U1138, 75006 Paris, France.
3 Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.
4 Université Pierre et Marie Curie/Paris VI, 75006 Paris.
5 Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
6 Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
7 Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, 17176 Stockholm, Sweden.
8 Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP; 75015 Paris, France.
Keywords:
autophagy, apoptosis, autosis, ferroptosis, MTP-driven regulated necrosis, necroptosis, parthanatos, pyroptosis.
Corresponding Author(s):
Conflict of interest statement:
The authors have no conflicts of interest to disclose.
Please cite this article as:
Lorenzo Galluzzi, Oliver Kepp and Guido Kroemer (2016). Mitochondrial regulation of cell death: a phylogenetically conserved control. Microbial Cell 3(3): 101-108. doi: 10.15698/mic2016.03.483
© 2016 Galluzzi et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Mitochondria are fundamental for eukaryotic cells as they participate in critical catabolic and anabolic pathways. Moreover, mitochondria play a key role in the signal transduction cascades that precipitate many (but not all) regulated variants of cellular demise. In this short review, we discuss the differential implication of mitochondria in the major forms of regulated cell death.