Yeast AP-1 like transcription factors (Yap) and stress response: a current overview
Authors:Claudina Rodrigues-Pousada1, Frédéric Devaux2, Soraia M. Caetano1, Catarina Pimentel1, Sofia da Silva1, Ana Carolina Cordeiro1 and Catarina Amaral1
doi: 10.15698/mic2019.06.679
Volume 6, pp. 267 to 285, published 28/05/2019.
1 Instituto de Tecnologia Química e Biológica Anónio Xavier, Universidade Nova de Lisboa, Avenida da República, EAN, Oeiras 2781-901, Oeiras, Portugal.
2 Sorbonne Université, CNRS, Institut de Biologie Paris-Seine, Laboratory of Computational and Quantitative Biology, F-75005, Paris, France.
Keywords:
yeast, Yap factors, cis-elements, bZIP, stress.
Corresponding Author(s):
Conflict of interest statement:
The authors have no conflict of interest to declare.
Please cite this article as:
Claudina Rodrigues-Pousada, Frédéric Devaux, Soraia M. Caetano, Catarina Pimentel, Sofia da Silva, Ana Carolina Cordeiro and Cata-rina Amaral (2019). Yeast AP-1 like transcription factors (Yap) and stress response: a current overview. Microbial Cell 6(6): 267-285. doi: 10.15698/mic2019.06.679
© 2019 Rodrigues-Pousada et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) li-cense, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Yeast adaptation to stress has been extensively studied. It involves large reprogramming of genome expression operated by many, more or less specific, transcription factors. Here, we review our current knowledge on the function of the eight Yap transcription factors (Yap1 to Yap8) in Saccharomyces cerevisiae, which were shown to be involved in various stress responses. More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds. Yap3 and Yap7 seem to be involved in hydroquinone and nitrosative stresses, respectively. The data presented in this article illustrate how much knowledge on the function of these Yap transcription factors is advanced. The evolution of the Yap family and its roles in various pathogenic and non-pathogenic fungal species is discussed in the last section.