Affiliations: Cell Cycle Laboratory, The Francis Crick Institute, I, Midland Road, London NW1 1AT, United Kingdom.
Keywords:
S. pombe, Ctr4, prion, Hsp104, fission yeast.
Corresponding Author(s):
Jacqueline Hayles, jacqueline.hayles@crick.ac.uk
Conflict of interest statement:
There is no conflict of interest resulting from this article.
Please cite this article as:
Jacqueline Hayles (2017). S. pombe placed on the prion map. Microbial Cell 4(2): 35-37.
© 2017 Hayles. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
S. pombe placed on the prion map
Authors:Jacqueline Hayles
doi: 10.15698/mic2017.02.555
Volume 4, pp. 35 to 37, published 03/02/2017.
Cell Cycle Laboratory, The Francis Crick Institute, I, Midland Road, London NW1 1AT, United Kingdom.
Keywords:
S. pombe, Ctr4, prion, Hsp104, fission yeast.
Corresponding Author(s):
Conflict of interest statement:
There is no conflict of interest resulting from this article.
Please cite this article as:
Jacqueline Hayles (2017). S. pombe placed on the prion map. Microbial Cell 4(2): 35-37.
© 2017 Hayles. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Schizosaccharomyces pombe has been used extensively as a model organism, however it is only recently that the first prion in this organism, a copper transporter protein encoded by ctr4, has been conclusively demonstrated. Prions are found in a wide range of organisms and have been implicated in a number of human neurodegenerative diseases. Research into the biology of prions has been carried out mainly in the budding yeast Saccharomyces cerevisiae, however there are many questions still to be addressed. Now, with the identification of the Ctr4 prion in S. pombe, further work in the two yeasts and comparisons of prion biology in these organisms should lead to a greater understanding of prions and their role in disease.