The integrated stress response in budding yeast lifespan extension
Authors:Spike D.L. Postnikoff1, Jay E. Johnson2 and Jessica K. Tyler1
doi: 10.15698/mic2017.11.597
Volume 4, pp. 368 to 375, published 24/10/2017.
1 Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065.
2 Orentreich Foundation for the Advancement of Science, Cold Spring, NY.
Keywords:
replicative lifespan, chronological lifespan, budding yeast, integrated stress response, autophagy.
Corresponding Author(s):
Conflict of interest statement:
The authors declare that they have no competing interests.
Please cite this article as:
Spike D.L. Postnikoff, Jay E. Johnson and Jessica K. Tyler (2017). The integrated stress response in budding yeast lifespan extension. Microbial Cell 4(11): 368-375. doi: 10.15698/mic2017.11.597
© 2017 Postnikoff et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion. The ultimate goal of aging research is to develop therapeutic means to extend human lifespan, while reducing susceptibility to many age-related diseases including cancer, as well as metabolic, cardiovascular and neurodegenerative disorders. However, this first requires elucidation of the causes of aging, which has been greatly facilitated by the use of model organisms. In particular, the budding yeast Saccharomyces cerevisiae has been invaluable in the identification of conserved molecular and cellular determinants of aging and for the development of approaches to manipulate these aging determinants to extend lifespan. Strikingly, where examined, virtually all means to experimentally extend lifespan result in the induction of cellular stress responses. This review describes growing evidence in yeast that activation of the integrated stress response contributes significantly to lifespan extension. These findings demonstrate that yeast remains a powerful model system for elucidating conserved mechanisms to achieve lifespan extension that are likely to drive therapeutic approaches to extend human lifespan and healthspan.