A novel antibacterial strategy: histone and antimicrobial peptide synergy

October 8, 2020

This article refers to the study "Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization" by Doolin et al. (Nat Comm, 2020) that shows that histones enhance the antimicrobial activity of peptides, disrupt bacterial membranes, and inhibit transcription, offering new insights into natural antimicrobial mechanisms.

Microbial wars: competition in ecological niches and within the microbiome

May 7, 2018

In this Editorial Bauer et al. provide a brief overview on microbial competition and discuss some of its roles and consequences that directly affect humans.

Antibiotic use in childhood alters the gut microbiota and predisposes to overweight

June 20, 2016

This article comments on work published by Korpela et al. (Nat Commun, 2016), which investigates the correlation between the use of antibiotics in early life and the excessive weight gain in later childhood.

Bactericidal antibiotics induce programmed metabolic toxicity

March 9, 2016

This article comments on work published by Lobritz et al. (PNAS, 2015), which demonstrates that bactericidal antibiotics induce metabolic perturbations that are linked to and required for bactericidal antibiotic toxicity.

Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs

September 23, 2014

This article comments on work published by Fluman et al. (Nat Comm, 2014), which describes the ability of bacterial multidrug transporters to move long molecules through the membrane in a processive manner.