FIGURE 1: Schematization of the activation of Snf1 and its main conventional functions. Snf1 complex is composed by the α subunit Snf1, the ƴ subunit Snf4 and one of three alternative β subunits Gal83, Sip1 or Sip2. Snf1 is phosphorylated on T210 by the upstream kinases Sak1, Tos3 and Elm1, while it is de-phosphorylated by the phosphatase complex Glc7/Reg1. When active, Snf1 phosphorylates transcription factors which regulate the expression of genes involved in glucose transport, stress response and glucose repression. In addition, Snf1 directly phosphorylates some metabolic enzymes. See text for details.