TABLE 1. Cellular roles of cathepsin D in physiological and pathological processes.
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52. Egberts F, Heinrich M, Jensen J-M, Winoto-Morbach S, Pfeiffer S, Wickel M, Schunck M, Steude J, Saftig P, Proksch E, and Schütze S (2004). Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. J Cell Sci 117(Pt 11): 2295–2307. http://dx.doi.org/10.1242/jcs.01075
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54. Kawada A, Hara K, Kominami E, Hiruma M, Noguchi H, and Ishibashi A (1997). Processing of cathepsins L, B and D in psoriatic epidermis. Arch Dermatol Res 289(2): 87–93. http://dx.doi.org/10.1007/s004030050160
55. Zhou W, Scott SA, Shelton SB, and Crutcher KA (2006). Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer’s disease. Neuroscience 143(3): 689–701. http://dx.doi.org/10.1016/j.neuroscience.2006.08.019
56. Kenessey A, Nacharaju P, Ko LW, and Yen SH (1997). Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration. J Neurochem 69(5): 2026–2038. http://dx.doi.org/10.1046/j.1471-4159.1997.69052026.x
57. Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand J-L, Desjardins F, Ansari A, Struman I, Nguyen NQN, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, and Drexler H (2007). A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 128(3): 589–600. http://dx.doi.org/10.1016/j.cell.2006.12.036
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60. Cullen V, Lindfors M, Ng J, Paetau A, Swinton E, Kolodziej P, Boston H, Saftig P, Woulfe J, Feany MB, Myllykangas L, Schlossmacher MG, and Tyynelä J (2009). Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Mol Brain 2: 5. http://dx.doi.org/10.1186/1756-6606-2-5
61. Haidar B, Kiss RS, Sarov-Blat L, Brunet R, Harder C, McPherson R, and Marcel YL (2006). Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux. J Biol Chem 281(52): 39971–39981. http://dx.doi.org/10.1074/jbc.M605095200
62. Durán MC, Martín-Ventura JL, Mohammed S, Barderas MG, Blanco-Colio LM, Mas S, Moral V, Ortega L, Tuñón J, Jensen ON, Vivanco F, and Egido J (2007). Atorvastatin modulates the profile of proteins released by human atherosclerotic plaques. Eur J Pharmacol 562(1-2): 119–129. http://dx.doi.org/10.1016/j.ejphar.2007.01.077