TABLE 1. Cellular roles of cathepsin D in physiological and pathological processes.

38. Vashishta A, Saraswat Ohri S, Vetvickova J, Fusek M, Ulrichova J, and Vetvicka V (2007). Procathepsin D secreted by HaCaT keratinocyte cells – A novel regulator of keratinocyte growth. Eur J Cell Biol 86(6): 303–313.

43. Saftig P, Hetman M, Schmahl W, Weber K, Heine L, Mossmann H, Köster A, Hess B, Evers M, and von Figura K (1995). Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J 14(15): 3599–3608.

44. Koike M, Shibata M, Ohsawa Y, Nakanishi H, Koga T, Kametaka S, Waguri S, Momoi T, Kominami E, Peters C, Figura K von, Saftig P, and Uchiyama Y (2003). Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci 22(2): 146–161.

45. Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E, Peters C, von Figura K, and Uchiyama Y (2000). Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci Off J Soc Neurosci 20(18): 6898–6906.

46. Koike M, Shibata M, Waguri S, Yoshimura K, Tanida I, Kominami E, Gotow T, Peters C, von Figura K, Mizushima N, Saftig P, and Uchiyama Y (2005). Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol 167(6): 1713–1728.

47. Zhang D, Brankov M, Makhija MT, Robertson T, Helmerhorst E, Papadimitriou JM, and Rakoczy PE (2005). Correlation between inactive cathepsin D expression and retinal changes in mcd2/mcd2 transgenic mice. Invest Ophthalmol Vis Sci 46(9): 3031–3038.

48. Steinfeld R, Reinhardt K, Schreiber K, Hillebrand M, Kraetzner R, Bruck W, Saftig P, and Gartner J (2006). Cathepsin D deficiency is associated with a human neurodegenerative disorder. Am J Hum Genet 78(6): 988–998.

49. Siintola E, Partanen S, Strömme P, Haapanen A, Haltia M, Maehlen J, Lehesjoki A-E, and Tyynelä J (2006). Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis. Brain J Neurol 129(Pt 6): 1438–1445.

50. Tyynelä J, Sohar I, Sleat DE, Gin RM, Donnelly RJ, Baumann M, Haltia M, and Lobel P (2001). Congenital ovine neuronal ceroid lipofuscinosis–a cathepsin D deficiency with increased levels of the inactive enzyme. Eur J Paediatr Neurol EJPN Off J Eur Paediatr Neurol Soc 5 Suppl A: 43–45.

51. Awano T, Katz ML, O’Brien DP, Taylor JF, Evans J, Khan S, Sohar I, Lobel P, and Johnson GS (2006). A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis. Mol Genet Metab 87(4): 341–348.

52. Egberts F, Heinrich M, Jensen J-M, Winoto-Morbach S, Pfeiffer S, Wickel M, Schunck M, Steude J, Saftig P, Proksch E, and Schütze S (2004). Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. J Cell Sci 117(Pt 11): 2295–2307.

53. Chen SH, Arany I, Apisarnthanarax N, Rajaraman S, Tyring SK, Horikoshi T, Brysk H, and Brysk MM (2000). Response of keratinocytes from normal and psoriatic epidermis to interferon-gamma differs in the expression of zinc-alpha(2)-glycoprotein and cathepsin D. FASEB J Off Publ Fed Am Soc Exp Biol 14(3): 565–571.

54. Kawada A, Hara K, Kominami E, Hiruma M, Noguchi H, and Ishibashi A (1997). Processing of cathepsins L, B and D in psoriatic epidermis. Arch Dermatol Res 289(2): 87–93.

55. Zhou W, Scott SA, Shelton SB, and Crutcher KA (2006). Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer’s disease. Neuroscience 143(3): 689–701.

56. Kenessey A, Nacharaju P, Ko LW, and Yen SH (1997). Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration. J Neurochem 69(5): 2026–2038.

57. Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand J-L, Desjardins F, Ansari A, Struman I, Nguyen NQN, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, and Drexler H (2007). A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 128(3): 589–600.

58. Sheikh AM, Li X, Wen G, Tauqeer Z, Brown WT, and Malik M (2010). Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects. Neuroscience 165(2): 363–370.

59. Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, and Simon H-U (2008). Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med 205(3): 685–698.

60. Cullen V, Lindfors M, Ng J, Paetau A, Swinton E, Kolodziej P, Boston H, Saftig P, Woulfe J, Feany MB, Myllykangas L, Schlossmacher MG, and Tyynelä J (2009). Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Mol Brain 2: 5.

61. Haidar B, Kiss RS, Sarov-Blat L, Brunet R, Harder C, McPherson R, and Marcel YL (2006). Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux. J Biol Chem 281(52): 39971–39981.

62. Durán MC, Martín-Ventura JL, Mohammed S, Barderas MG, Blanco-Colio LM, Mas S, Moral V, Ortega L, Tuñón J, Jensen ON, Vivanco F, and Egido J (2007). Atorvastatin modulates the profile of proteins released by human atherosclerotic plaques. Eur J Pharmacol 562(1-2): 119–129.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.