FIGURE 2: Network of Snf1 physical interactors. The network reports the known physical associations obtained from SGD (Saccharomyces Genome Database, http://www.yeastgenome.org). Interactors are clustered according to their function and colored differently. When the interactor is also a substrate of Snf1 according to the Yeast Kinase Interaction Database (KID, http://www.moseslab.csb.utoronto.ca/KID/; [44]), the edge is colored in red if phosphorylation was analyzed by low throughput assays (LTP in vitro kinase assays; in vitro phosphorylation site mapping; in vivo phosphorylation site mapping; phosphorylation reduced or absent in kinase mutant) or in blue if phosphorylation was assayed only by high throughput analysis (protein chip data for in vitro phosphorylated substrate; HTP in vitro phosphorylation). Data visualization and analysis was performed with Cytoscape [45].

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