FIGURE 1: Possible cascade of events triggered when s2U, mcm5U or t6A levels are reduced in tRNALysUUU.

Alteration in the levels of mcm5s2U occurring at position 34 of the tRNA (wobble position) and t6A occurring at position 37 (adjacent to the first base of the anti-codon) have global cellular affects. Reduction in either modification alters many regulatory cascades with the text color indicating the modification responsible for the change (red indicates expression change seen in t6A and mcm5s2U mutants). Solid lines represent experimental data; dashed lines indicated potential points of regulation.

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