(A) Structures of cis and trans proline and a schematic of the histone H3 N-terminal tail with proline 16 in the two possible conformations.
(B) Distribution of H3K14ac and H3K4me3 across a typical gene in yeast.
(C) The changes in RNA level of oxidative (green) and reductive (red) genes during the yeast metabolic cycle.

(D) Environmental signals lead to dynamic H3K14ac, H3P16 isomerization and altered H3K4me3 in vivo.

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