(A) General mechanism for H+-coupled solute antiport. Note that most transporters have an internal 2-fold symmetry axis and a monomeric transporter is represented here by two symmetrical parts, shown in light blue. The substrate is indicated by orange sphere. The occluded state is second from the left.

(B) Chemical structure of divalent cationic drugs that are transported or untransported by MdfA.

(C) Illustration of the suggested processive antiport mechanism.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.