FIGURE 1: Dihydroartemisinin (DHA) inhibits yeast on both fermentable and nonfermentable media, albeit at much higher levels for the latter. Artemisinin (ART) has much weaker inhibition on the fermentable medium.

(A) Molecular structures of ART and DHA. The endoperoxide bond in 1, 2, 4-trioxane is critical for the action of this class of drugs.

(B) Inhibition of yeast growth on fermentable (YPD) and nonfermentable (YPGE) media with ART and DHA. DMSO was used when there was no drug added.

ART: artemisinin; DHA: dihydroartemisinin.

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