FIGURE 2: A model for Lem2 function in heterochromatin localization and silencing.

Lem2 mediates anchoring to the nuclear periphery of centromeres and telomeres through its LEM domain and MSC domain, respectively. Silencing of both heterochromatin domains is mediated exclusively through its MSC domain. Both functions cooperate with other redundant pathways (i.e. Csi1, RNAi, Taz1). See text for details.

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