FIGURE 2: PolyQ-induced toxicity in CLS models of yeast aging is suppressed by HAP4 overexpression-mediated increase in mitochondrial biogenesis.

(A) Endogenous cell respiration during the exponential and stationary phases of growth of non-induced and induced 103Q cultures overexpressing or not HAP4. Bars represent mean ± S.D., n = 3.

(B) Effect of increased mitochondrial biogenesis by HAP4 overexpression on CLS of yeast expressing 103Q from day 0 in the stationary phase. Error bars represent S.E.M. for 3 independent experiments.

(C) PolyQ expression levels at day 1 after β-estradiol induction estimated by flow cytometry quantification of GFP fluorescence.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.