FIGURE 4: Genes regulated by multiple signaling pathways in response to alkaline pH stress.

Expression profiles have been collected from published transcriptomic data [18,22,36,56,68,97]. Gene Ontology analyses were based on FuncAssociate 2.0 [128] and YeastMine [129]. Numbers in parentheses denote the p-value for a given category.

18. Viladevall L, Serrano, R, Ruiz, A, Domenech, G, Giraldo, J, Barcelo, A, and Arino, J (2004). Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae. J Biol Chem 279(42): 43614-43624.

22. Serrano R, Martin, H, Casamayor, A, and Arino, J (2006). Signaling alkaline pH stress in the yeast Saccharomyces cerevisiae through the Wsc1 cell surface sensor and the Slt2 MAPK pathway. J Biol Chem 281(52): 39785-39795.

36. Ruiz A, Serrano R, and Arino J (2008). Direct regulation of genes involved in glucose utilization by the calcium/calcineurin pathway. J Biol Chem 283(20): 13923-13933.

56. Casamayor A, Serrano R, Platara M, Casado C, Ruiz A, and Arino J (2012). The role of the Snf1 kinase in the adaptive response of Saccharomyces cerevisiae to alkaline pH stress. Biochem J 444(1): 39-49.

68. Casado C, Gonzalez A, Platara M, Ruiz A, and Arino J (2011). The role of the protein kinase A pathway in the response to alkaline pH stress in yeast. Biochem J 438(3): 523-533.

97. Lamb TM, Xu, W, Diamond, A, and Mitchell, AP (2001). Alkaline response genes of Saccharomyces cerevisiae and their relationship to the RIM101 pathway. J Biol Chem 276(3): 1850-1856.

128. Berriz GF, Beaver JE, Cenik C, Tasan M, and Roth FP (2009). Next generation software for functional trend analysis. Bioinformatics 25(22): 3043-3044.

129. Balakrishnan R, Park J, Karra K, Hitz BC, Binkley G, Hong EL, Sullivan J, Micklem G, and Cherry JM (2012). YeastMine–an integrated data warehouse for Saccharomyces cerevisiae data as a multipurpose tool-kit. Database (Oxford) 2012 bar062-.