FIGURE 5: Transmission electron microscopy (TEM) of Epon-embedded cells. Parasites were treated with 1.4 μM Erg-GTr, 2.3 μM Erg-GTr2 or DMSO (control cells), harvested after 48 hours and prepared for TEM.

(A) The most obvious alterations in Erg-GTr-treated cells are as follows: increase of vacuolar structures containing cytoplasmic material (c, d, f, h), myelin-like structures (d, h), increase of lysosomes (d, e, g), and flagellar pocket containing some material (g). Note the usual appearance of mitochondria, nucleus and cytoplasmic content in control cells (a, b). Abbreviations used: lysosome (L); nucleus (N); flagellar pocket (FP); mitochondrion (M). Arrows and asterisk indicate autophagosomes and myelin-like structures, respectively.

(B) Mitochondrion zoom in to show cristae. More than 50% of the Erg-GTr treated parasites showed increase in cristae number and size. Bars represent 0.5 μm each.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.