FIGURE 8: Model for the cellular response to reduction of t6A.

(1) Reduction of threonine lowers the level of t6A and (2) decreases the activity of the master controller Tor, which reduces anabolism and the growth potential of the cell through multiple pathways. (3) ~300 proteins only use t6A encoding tRNAs for arginine. (4) Potential outcomes of increased translation ambiguities seen in the absence of t6A.

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