Back to article: Decreasing cytosolic translation is beneficial to yeast and human Tafazzin-deficient cells


FIGURE 5: Partially decreasing cytosolic translation in taz1Δ yeast preserves a normal production of ROS. The cells were grown in CSM containing 0.5% galactose + 2% ethanol at 36°C for 48 hours. At the indicated times, ROS levels were measured by flow cytometry using dihydroethidium as a probe. The data are expressed in % relative to the WT at T0 (n=3). Statistical analysis was done with Tukey’s test (*P<0.05; **P<0.01; ***P<0.001; ****P<0.0001). The data for WT and taz1Δ strains were reported previously [60].

60. de Taffin de Tilques M, Tribouillard-Tanvier D, Tetaud E, Testet E, di Rago JP, Lasserre JP (2017). Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome. Dis Model Mech 10(4): 439-450.

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