Table 1: Nucleotide sequence of mitochondrial mutations suppressed either by the 15S mitochondrial ribosomal RNA mutation mim3-1 or by the dominant nuclear mutation Nam9-1 encoding the ribosomal protein S4 or by the recessive nuclear mutation nam3-1.

The mutated site is given with its surrounding context. The base present in the mutant is indicated in bold characters, above the mutated codon which is underlined. ORF-bi2 and ORF-bi4: Open reading frames coding for RNA-maturase of the second and fourth introns of the cytochrome b gene respectively; COX2: uninterrupted gene encoding the subunit II of cytochrome oxidase; fs: frameshift mutation. The results of suppression are from [5, 6] for nam3-1 and mim3-1 and [12] for NAM9-1. The numbers correspond to the distance of the nucleotide sequence, in base pairs, from the first base of the initiation codon ATG.

5. Kruszewska A, Slonimski PP (1984a) Mitochondrial and nuclear mitoribosomal suppressors that enable misreading of ochre codons in yeast mitochondria. I. Isolation, localization and allelism of sup-pressors. Curr Genet 9: 1-10.

6. Kruszewska A, Slonimski PP (1984b) Mitochondrial and nuclear mitoribosomal suppressors that enable misreading of ochre codons in yeast mitochondria. II Specificity and extent of suppressor action. Curr Genet 9: 11-19.

7. Fox TD, Staempfli S (1982) Suppressor of yeast mitochondrial ochre mutations that maps in or near the 15S ribosomal RNA gene of mtDNA. Proc Natl Acad Sci USA 79: 1583-7.

12. Boguta M, Dmochowska A, Borsuk P, Wrobel K, Gargouri A, Lazowska J, Slonimski P, Szczesniak B, Kruszewska A (1992) Nam9 nuclear suppressor of mitochondrial ochre mutations in Saccharo-myces cerevisiae codes fro a protein homologous to S4 ribosomal proteins from Chloroplasts, Bacteria and Eucaryotes. Mol Cel Biol 12: 402-412.

16. Jacq C, Pajot P, Lazowska J, Dujardin G, Glaisse M, Groudinsky O, De la sale H, Grand-champ C, Labouesse M, Gargouri A, Guiard B, Spyridakis A, Dreyfus M, Slonimski PP (1982) Role of introns in the yeast cytochrome b gene: cis and transacting signals, intron manipulation, expression and intergenic expression. In: Mitochondrial genes. Monograph 12. Cold Spring harbor Lab, New York, pp155-183.

43. Lazowska J, Jacq C, Slonimski PP (1980) Sequence of introns and flanking exons in wild type and box3 mutants of cytochrome reveals an interlaced splicing protein coded by an exon. Cell 22: 333-348.

47. Guiso N, Dreyfus M, Siffert O, Danchin A, Spyridakis A, Gargouri A, Claisse M, Slonimski PP (1984) Antibodies against synthetic oligopeptides allow identification of the mRNA-maturase encoded by the second intron of the yeast cob-box gene. EMBO J 3: 1567-1572.

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