TABLE 1. Histone modifications involved in aging and apoptotic processes in yeast.

The implications listed are referring to the respective histone modifications. The listed writers and erasers may have impact on other histone modifications not related to cell death as well and the modifiers may have targets other than the histones, which may implicate them in other cell death pathways.

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129. Smith JS, Boeke JD (1997). An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev 11(2): 241-254.

143. Chen CC, Carson JJ, Feser J, Tamburini B, Zabaronick S, Linger J, Tyler JK (2008). Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell 134(2): 231-243.

152. Downs JA, Lowndes NF, Jackson SP (2000). A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 408(6815): 1001-1004.

153. Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ (2006). A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 439(7075): 497-501.

154. Liang G, Klose RJ, Gardner KE, Zhang Y (2007). Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. Nat Struct Mol Biol 14(3): 243-245.

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157. Lee JH, Kang BH, Jang H, Kim TW, Choi J, Kwak S, Han J, Cho EJ, Youn HD (2015). AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage. Nucleic Acids Res 43(9): 4505-4516.

158. Hiraga S, Botsios S, Donaldson AD (2008). Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioning. J Cell Biol 183(4): 641-651.

159. Kozak ML, Chavez A, Dang W, Berger SL, Ashok A, Guo X, Johnson FB (2010). Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. EMBO J 29(1): 158-170.

160. Vaquero A, Sternglanz R, Reinberg D (2007). NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene 26(37): 5505-5520.

161. Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frohlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009). Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11): 1305-1314.

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