Review, Reviews
Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles
Sónia Castanheira1, Juan J. Cestero1, Francisco García-del Portillo1, M. Graciela Pucciarelli1,2,3
In this article, the authors comment on the study "A Specialized Peptidoglycan Synthase Promotes Salmonella Cell Division inside Host Cells" by Castanheira et al. (mBio, 2017), discussing insights in two distinct penicillin binding proteins that promote cell division in different Salmonella lifestyles.
New perspectives from South-Y-East, not all about deathA report of the 12th lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017
Nicoletta Guaragnella1,#, Mariarita Stirpe2,#, William Burhans3, Manuela Côrte-Real4, Campbell Gourlay5, Paula Ludovico6,7, Frank Madeo8,9, Dina Petranovic10, Joris Winderickx11, Cristina Mazzoni2 and Sergio Giannattasio1
In this article Guaragnella et al. report on the 12th International Meeting on Yeast Apoptosis (IMYA12), which was held in Bari, Italy from May 14th to 18th, 2017, where more than 100 participants, among which senior and young scientists from Europe, USA, North Africa and Japan, had an intense and open exchange of achievements and ideas in the field of yeast regulated cell death (RCD).
pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity
Marie-Anne Deprez1,°, Elja Eskes1,°, Tobias Wilms1, Paula Ludovico2, Joris Winderickx1
In this article, Deprez et al. discuss accumulating evidence indicates that pH homeostasis plays a prominent role in the determination of ageing and longevity, thereby providing new perspectives and avenues to explore the underlying molecular mechanisms.
Guidelines and recommendations on yeast cell death nomenclature
Didac Carmona-Gutierrez1,‡,*, Maria Anna Bauer1,‡, Andreas Zimmermann1, Andrés Aguilera2, Nicanor Austriaco3, Kathryn Ayscough4, Rena Balzan5, Shoshana Bar-Nun6, Antonio Barrientos7,8, Peter Belenky9, Marc Blondel10, Ralf J. Braun11, Michael Breitenbach12, William C. Burhans13, Sabrina Büttner1,14, Duccio Cavalieri15, Michael Chang16, Katrina F. Cooper17, Manuela Côrte-Real18, Vítor Costa19–21, Christophe Cullin22, Ian Dawes23, Jörn Dengjel24, Martin B. Dickman25, Tobias Eisenberg1,26, Birthe Fahrenkrog27, Nicolas Fasel28, Kai-Uwe Fröhlich1, Ali Gargouri29, Sergio Giannattasio30, Paola Goffrini31, Campbell W. Gourlay32, Chris M. Grant33, Michael T. Greenwood34, Nicoletta Guaragnella30, Thomas Heger35, Jürgen Heinisch36, Eva Herker37, Johannes M. Herrmann38, Sebastian Hofer1, Antonio Jiménez-Ruiz39, Helmut Jungwirth1, Katharina Kainz1, Dimitrios P. Kontoyiannis40, Paula Ludovico41,42, Stéphen Manon43, Enzo Martegani44, Cristina Mazzoni45, Lynn A. Megeney46–48, Chris Meisinger49, Jens Nielsen50–52, Thomas Nyström53, Heinz D. Osiewacz54, Tiago F. Outeiro55–58, Hay-Oak Park59, Tobias Pendl1, Dina Petranovic50,51, Stephane Picot60,61, Peter Polčic62, Ted Powers63, Mark Ramsdale64, Mark Rinnerthaler65, Patrick Rockenfeller1,32, Christoph Ruckenstuhl1, Raffael Schaffrath66, Maria Segovia67, Fedor F. Severin68, Amir Sharon69, Stephan J. Sigrist70, Cornelia Sommer-Ruck1, Maria João Sousa18, Johan M. Thevelein71,72, Karin Thevissen73, Vladimir Titorenko74, Michel B. Toledano75, Mick Tuite32, F.-Nora Vögtle49, Benedikt Westermann11, Joris Winderickx76, Silke Wissing77, Stefan Wölfl78, Zhaojie J. Zhang79, Richard Y. Zhao80, Bing Zhou81, Lorenzo Galluzzi82–84,*, Guido Kroemer84–90,*, Frank Madeo1,26,*
In this review, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death routines that are relevant for the biology of yeast.
Burkholderia gladioli strain NGJ1 deploys a prophage tail-like protein for mycophagy
Rahul Kumar1, Sunil Kumar Yadav1, Durga Madhab Swain1 and Gopaljee Jha1
In this article, the authors comment on the study "A prophage tail-like protein is deployed by Burkholderia bacteria to feed on fungi" by Swain et al. (Nature Communications, 2017), discussing that a prophage tail-like protein (Bg_9562) is essential for mycophagy. The protein may help the bacteria to survive in certain ecological niches and, considering its broad-spectrum antifungal activity, may be potentially useful in biotechnological applications to control fungal diseases.
Ras signalling in pathogenic yeasts
Daniel R. Pentland1, Elliot Piper-Brown1, Fritz A. Mühlschlegel1,2 and Campbell W. Gourlay1
In this article Pentland et al. review the roles of Ras protein function and signalling in the major human yeast pathogens Candida albicans and Cryptococcus neoformans and discuss the potential for targeting Ras as a novel approach to anti-fungal therapy.
A novel basolateral type IV secretion model for the CagA oncoprotein of Helicobacter pylori
Silja Wessler1 and Steffen Backert2
In this article, the authors comment on the study "Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery" by Tegtmeyer et al. (Cell Host Microbe, 2017), discussing that the finding of a T4SS receptor suggests the presence of a sophisticated control mechanism for the injection of CagA and the possible impact of this novel signaling cascade on pathogenesis during infection with Helicobacter pylori.
A new role for the nuclear basket network
Paola Gallardo1, Silvia Salas-Pino1 and Rafael R. Daga1
This article comments on work published by Salas-Pino et al. (J Cell Biol, 2017), which describes a novel function of the fission yeast nuclear basket component - the translocated promoter region (TPR) nucleoporin Alm1 - in proper localization of the proteasome to the nuclear envelope.
pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity
January 12, 2018
In this article, Deprez et al. discuss accumulating evidence indicates that pH homeostasis plays a prominent role in the determination of ageing and longevity, thereby providing new perspectives and avenues to explore the underlying molecular mechanisms.
Guidelines and recommendations on yeast cell death nomenclature
January 1, 2018
In this review, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death routines that are relevant for the biology of yeast.
Burkholderia gladioli strain NGJ1 deploys a prophage tail-like protein for mycophagy
December 31, 2017
In this article, the authors comment on the study "A prophage tail-like protein is deployed by Burkholderia bacteria to feed on fungi" by Swain et al. (Nature Communications, 2017), discussing that a prophage tail-like protein (Bg_9562) is essential for mycophagy. The protein may help the bacteria to survive in certain ecological niches and, considering its broad-spectrum antifungal activity, may be potentially useful in biotechnological applications to control fungal diseases.
Ras signalling in pathogenic yeasts
December 18, 2017
In this article Pentland et al. review the roles of Ras protein function and signalling in the major human yeast pathogens Candida albicans and Cryptococcus neoformans and discuss the potential for targeting Ras as a novel approach to anti-fungal therapy.
A novel basolateral type IV secretion model for the CagA oncoprotein of Helicobacter pylori
December 9, 2017
In this article, the authors comment on the study "Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery" by Tegtmeyer et al. (Cell Host Microbe, 2017), discussing that the finding of a T4SS receptor suggests the presence of a sophisticated control mechanism for the injection of CagA and the possible impact of this novel signaling cascade on pathogenesis during infection with Helicobacter pylori.
A new role for the nuclear basket network
November 28, 2017
This article comments on work published by Salas-Pino et al. (J Cell Biol, 2017), which describes a novel function of the fission yeast nuclear basket component - the translocated promoter region (TPR) nucleoporin Alm1 - in proper localization of the proteasome to the nuclear envelope.
VAMP8 mucin exocytosis attenuates intestinal pathogenesis by Entamoeba histolytica
November 24, 2017
This article comments on work published by Cornick et al. (mBio, 2017), which nominates SNARE-mediated exocytosis as the putative mechanism responsible for pathogen-induced mucus secretion from goblet cells.
Shutdown of interferon signaling by a viral-hijacked E3 ubiquitin ligase
November 3, 2017
This article comments on work published by Davis et al. (mBio, 2017), which describes molecular requirements that govern NSP1 recognition of β-TrCP, including an essential degron phosphorylation event, and the step-wise incorporation of NSP1 into hijacked cullin-RING E3 ligases (CRLs) that ubiquitinate and tag β-TrCP for degradation.
Breaking the bad: Bacillus blocks fungal virulence factors
October 30, 2017
This article comments on work published by Mayer & Kronstad (mBio, 2017), which identified the soil bacterium, Bacillus safensis as a potent inhibitor of virulence factor production by two major fungal pathogens of humans, Cryptococcus neoformans, and Candida albicans.