Publications

A cobalt concentration sensitive Btu-like system facilitates cobalamin uptake in Anabaena sp. PCC 7120

February 20, 2024

Metal homeostasis is central to all forms of life, as metals are essential micronutrients with toxic effects at elevated levels. Our results provide novel information on the uptake of cobalamin and the regulation of the cellular cobalt content in cyanobacteria.

Predictable regulation of survival by intratumoral microbe-immune crosstalk in patients with lung adenocarcinoma

February 19, 2024

Intratumoral microbiota can regulate the tumor immune microenvironment (TIME) and mediate tumor prognosis by promoting inflammatory response or inhibiting anti-tumor effects. Our study demonstrated that intratumoral microbiota-immune crosstalk was strongly associated with prognosis in LUAD patients, which would provide new targets for the development of precise therapeutic strategies.

Two TonB-dependent outer membrane transporters involved in heme uptake in Anabaena sp. PCC 7120

January 9, 2024

Low availability of micronutrients such as iron has enforced the evolution of uptake systems in all kingdoms of life. In our study, we conclude that heme transport might not be restricted to Anabaena, but at the same time is not specific to a cyanobacterial order and thus might be related to the habitat of origin, a notion which needs to be challenged in the future.

The last two transmembrane helices in the APC-type FurE transporter act as an intramolecular chaperone essential for concentrative ER-exit

January 5, 2024

FurE is a H+ symporter specific for the cellular uptake of uric acid, allantoin, uracil, and toxic nucleobase analogues in the fungus Aspergillus nidulans. Being member of the NCS1 protein family, FurE is structurally related to the APC-superfamily of transporters.

Extracellular DNA secreted in yeast cultures is metabolism-specific and inhibits cell proliferation

November 23, 2023

Our study demonstrates that extracellular DNA released by living cells can impact the growth rate of Saccharomyces cerevisiae cultures, showing similarities to extrachromosomal circular DNA and leading to cell cycle arrest in the S phase, suggesting potential new functional roles of exDNA.

The Hrk1 kinase is a determinant of acetic acid tolerance in yeast by modulating H⁺ and K⁺ homeostasis

November 14, 2023

INTRODUCTION The yeast Saccharomyces cerevisiae must constantly adapt to changing and challenging environments, both in nature and industrial bioprocesses, to thrive and maintain cellular homeostasis under a wide range of

Basal level of ppGpp coordinates Escherichia coli cell heterogeneity and ampicillin resistance and persistence

October 25, 2023

The universal stringent response alarmone ppGpp (guanosine penta and tetra phosphates) plays a crucial role in various aspects of fundamental cell physiology (e.g., cell growth rate, cell size) and thus bacterial tolerance to and survival of external stresses, including antibiotics. In tihs study, we discuss the fundamental role of basal level of ppGpp in regulating cell homogeneity and ampicillin persistence.

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