Regulation of anti-microbial autophagy by factors of the complement system

Authors:

Christophe Viret1, Aurore Rozières1, Rémi Duclaux-Loras1, Gilles Boschetti1, Stéphane Nancey1 and
Mathias Faure1,2

doi: 10.15698/mic2020.04.712
Volume 7, pp. 93 to 105, published 19/03/2020.

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Affiliations:

1 CIRI, Centre International de Recherche en Infectiologie, Team Autophagy Infection Immunity, Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.

2 Equipe Labellisée par la Fondation pour la Recherche Médicale, FRM.

Keywords: 

autophagy, complement, immunity, infection, bacteria, virus, homeostasis

Corresponding Author(s):

Christophe Viret, CIRI, INSERM U1111, CNRS UMR 5308, ENS-L, UCBL1 - 21, Avenue Tony Garnier 69365 Lyon Cedex 07, France. Phone: +33 4 37 28 23 42. Fax: +33 4 37 28 23 77; christophe.viret@inserm.fr

Conflict of interest statement:

We report no conflict of interest.

Please cite this article as:

Christophe Viret, Aurore Rozières, Rémi Duclaux-Loras, Gilles Boschetti, Stéphane Nancey and Mathias Faure (2020). Regulation of anti-microbial autophagy by factors of the complement system. Microbial Cell 7(4): 93-105. doi: 10.15698/mic2020.04.712

© 2020 Viret et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.

Abstract:

The complement system is a major component of innate immunity that participates in the defense of the host against a myriad of pathogenic microorganisms. Activation of complement allows for both local inflammatory response and physical elimination of microbes through phagocytosis or lysis. The system is highly efficient and is therefore finely regulated. In addition to these well-established properties, recent works have revealed that components of the complement system can be involved in a variety of other functions including in autophagy, the conserved mechanism that allows for the targeting and degradation of cytosolic materials by the lysosomal pathway after confining them into specialized organelles called autophagosomes. Besides impacting cell death, development or metabolism, the complement factors-autophagy connection can greatly modulate the cell autonomous, anti-microbial activity of autophagy: xenophagy. Both surface receptor-ligand interactions and intracellular interactions are involved in the modulation of the autophagic response to intracellular microbes by complement factors. Here, we review works that relate to the recently discovered connections between factors of the complement system and the functioning of autophagy in the context of host-pathogen relationship.