The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae
Authors:Chang-Lin Chen1,a, Wei-Ling Huang1, Alexander Rapoport2, Rimantas Daugelavičius3 and Chuang-Rung Chang1
1 Institute of Biotechnology, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu City, 300044, Taiwan. 2 Institute of Microbiology and Biotechnology, Faculty of Medicine and Life Sciences, University of Latvia, Jelgavas Str., 1-537, Riga, LV-1004, Latvia. 3 Research Institute of Natural and Technological Sciences, Vytautas Magnus University, K. Donelaičio str. 58, 44248, Kaunas, Lithuania. a Current address: Facility Division, National Synchrotron Radiation Research Center, 101, Hsin-Ann Road, Hsinchu City, 300092, Taiwan.
Keywords:
mitochondria, yeast, dynamic organelles.
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Conflict of interest statement:
The authors declare no conflicts of interest.
Please cite this article as:
Chang-Lin Chen, Wei-Ling Huang, Alexander Rapoport, Rimantas Daugelavičius and Chuang-Rung Chang (2025). The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae. Microbial Cell 12: 242-254. doi: 10.15698/mic2025.08.859
© 2025 Chen et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Mitochondria are essential organelles that form a dynamic network within cells. The fusion, fission, and transport processes among mitochondria must reach a balance, which is achieved through complex regulatory mechanisms. These dynamic processes and regulatory pathways are highly conserved across species and are coordinated to help cells respond to environmental stress. The budding yeast Saccharomyces cerevisiae has become an important model organism for studying mitochondria dynamics due to its genetic tractability and the conservation of key mitochondrial regulators. Previous research on mitochondria dynamics in yeast has provided valuable insights into the regulatory pathways in eukaryotic cells. It has helped to elucidate the mechanisms related to diseases associated with disrupted mitochondria dynamics. This review explores the molecular mechanisms underlying mitochondria dynamics and their physiological roles in Saccharomyces cerevisiae. The knowledge we learned from the primary eukaryotic yeast cell will aid us in advancing future research on the regulatory mechanisms of mitochondria in both health and disease.
doi: 10.15698/mic2025.08.859
Volume 12, pp. 242 to 254, published 27/08/2025.