De novo peroxisome biogenesis revisited
Authors:Marten Veenhuis and Ida J. van der Klei
Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.
Keywords:
yeast, peroxisomes, de novo peroxisome formation, peroxisome deficient mutant, endoplasmic reticulum.
Related Article(s)?
Knoops K, Manivannan S, Cepinska MN, Krikken AM, Kram AM, Veenhuis M, van der Klei IJ (2014). Preperoxisomal vesicles can form in the absence of Pex3. J Cell Biol 204(5):659-68. , 10.1083/jcb.201310148
Corresponding Author(s):
Conflict of interest statement:
The authors declare no competing financial interests.
Please cite this article as:
Marten Veenhuis and Ida J. van der Klei (2014). De novo peroxisome biogenesis revisited. Microbial Cell 1(4): 128-130.
© 2014 Veenhuis and van der Klei. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.
Abstract:
We describe an alternative peroxisome formation pathway in yeast pex3 and pex19 cells, which relies on the existence of small peroxisomal remnants that are present in these cells. This groundbreaking result challenges current models prescribing that peroxisomes derive de novo from the ER. Our data also has major implications for the sorting pathway of specific peroxisomal membrane proteins (PMPs). We propose a novel sorting pathway for the PMPs Pex13 and Pex14 that is independent of the known Pex3/Pex19 machinery.
doi: 10.15698/mic2014.04.138
Volume 1, pp. 128 to 130, published 01/04/2014.