Affiliations: 1 Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
2 Department of Medicine University of Virginia, Charlottesville, VA, USA.
3 Department of Pathology, University of Virginia, Charlottesville, VA, USA.
Keywords:
amebiasis, entamoeba, trogocytosis, cytotoxicity
Corresponding Author(s):
William A. Petri, Jr., M.D., Ph.D., Chief, Infectious Diseases & International Health, 1709A Carter-Harrison Bldg., University of Virginia 22908-1340; wap3g@virginia.edu
Conflict of interest statement:
The authors declare that they do not have any conflict of interest.
Please cite this article as:
Allissia A. Gilmartin and William A. Petri, Jr (2017). Exploring the mechanism of amebic trogocytosis: the role of amebic lysosomes Microbial Cell 5(1): 1-3. doi: 10.15698/mic2018.01.606
© 2017 Gilmartin and Petri. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Exploring the mechanism of amebic trogocytosis: the role of amebic lysosomes
Authors:Allissia A. Gilmartin1 and William A. Petri, Jr1,2,3
doi: 10.15698/mic2018.01.606
Volume 5, pp. 1 to 3, published 06/12/2017.
1 Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
2 Department of Medicine University of Virginia, Charlottesville, VA, USA.
3 Department of Pathology, University of Virginia, Charlottesville, VA, USA.
Keywords:
amebiasis, entamoeba, trogocytosis, cytotoxicity
Corresponding Author(s):
Conflict of interest statement:
The authors declare that they do not have any conflict of interest.
Please cite this article as:
Allissia A. Gilmartin and William A. Petri, Jr (2017). Exploring the mechanism of amebic trogocytosis: the role of amebic lysosomes Microbial Cell 5(1): 1-3. doi: 10.15698/mic2018.01.606
© 2017 Gilmartin and Petri. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
In this article, the authors comment on trogocytosis, the process where cells transfer material among each other, is linked to both disease mechanisms and immune responses. The protozoan Entamoeba histolytica demonstrates this through a nibbling process known as amebic trogocytosis that is crucial for its pathogenicity. Research has shown that the acidification of amebic lysosomes is essential for the continuation of trogocytosis and the efficient destruction of human cells. Inhibition of lysosome acidification reduces both trogocytosis and cell death, suggesting the possibility of new therapeutic strategies against amebic pathogenesis and prompting further investigation into the exact role of lysosomes in this process.