Genome evolution in yeast reveals connections between rare mutations in human cancer
Authors:Xinchen Teng1,2 and J. Marie Hardwick2
doi: 10.15698/mic2014.06.153
Volume 1, pp. 206 to 209, published 02/06/2014.
1 College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province 215123, PRChina.
2 W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205 USA.
Keywords:
yeast knockouts, genome evolution, secondary mutations, cancer progression.
Corresponding Author(s):
Conflict of interest statement:
The authors declare no competing financial interests.
Please cite this article as:
Xinchen Teng and J. Marie Hardwick (2014). Genome evolution in yeast reveals connections between rare mutations in human cancers. Microbial Cell 1(6): 206-209.
© 2014 Teng and Hardwick. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.