Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing
Authors:Belém Sampaio-Marques1,2, William C. Burhans3, Paula Ludovico1,2
1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
2 ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal.
3 Dept. of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Keywords:
nutrient-sensing pathways, autophagy, mitophagy, chronological lifespan, replicative lifespan, ageing, yeast.
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Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Belém Sampaio-Marques, William C. Burhans, Paula Ludovico (2014). Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing. Microbial Cell 1(4): 118-127.
© 2014 Sampaio-Marques et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Ageing is a complex and multi-factorial process that results in the progressive accumulation of molecular alterations that disrupt different cellular functions. The budding yeast Saccharomyces cerevisiae is an important model organism that has significantly contributed to the identification of conserved molecular and cellular determinants of ageing. The nutrient-sensing pathways are well-recognized modulators of longevity from yeast to mammals, but their downstream effectors and outcomes on different features of ageing process are still poorly understood. A hypothesis that is attracting increased interest is that one of the major functions of these “longevity pathways” is to contribute to the maintenance of the proteome during ageing. In support of this hypothesis, evidence shows that TOR/Sch9 and Ras/PKA pathways are important regulators of autophagy that in turn are essential for healthy cellular ageing. It is also well known that mitochondria homeostasis and function regulate lifespan, but how mitochondrial dynamics, mitophagy and biogenesis are regulated during ageing remains to be elucidated. This review describes recent findings that shed light on how longevity pathways and metabolic status impact maintenance of the proteome in both yeast ageing paradigms. These findings demonstrate that yeast remain a powerful model system for elucidating these relationships and their influence on ageing regulation.
doi: 10.15698/mic2014.04.136
Volume 1, pp. 118 to 127, published 07/04/2014.