Subverting lysosomal function in Trypanosoma brucei

Authors:

Sam Alsford

doi: 10.15698/mic2015.08.222
Volume 2, pp. 259 to 261, published 03/08/2015.

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Affiliations:

London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

Keywords: 

Trypanosoma brucei, lysosome, LeuLeu-OMe

Corresponding Author(s):

Sam Alsford, sam.alsford@lshtm.ac.uk

Conflict of interest statement:

I have no conflicts of interest.

Please cite this article as:

Sam Alsford (2015). Subverting lysosomal function in Trypanosoma brucei. Microbial Cell 2(8): 259-261.

© 2015 Alsford. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.

Abstract:

In this issue of Microbial Cell, Koh and colleagues present data highlighting the utility of the lysosomotropic compound L-leucyl-L-leucyl methyl ester (LeuLeu-OMe) as an anti-Trypanosoma brucei agent, adding to the range of compounds that either directly target lysosomal enzymes or that can be used to subvert the function of the lysosome for parasite destruction.