The translationally controlled tumor protein TCTP is involved in cell cycle progression and heat stress response in the bloodstream form of Trypanosoma brucei
Authors:Borka Jojic1, Simona Amodeo1,2 and Torsten Ochsenreiter1
doi: 10.15698/mic2018.10.652
Volume 5, pp. 460 to 468, published 24/08/2018.
1 Institute of Cell Biology, University of Bern, Bern, Switzerland.
2 Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Keywords:
TCTP, Trypanosoma brucei, mitochondria, heat stress response, acidocalcisomes
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Borka Jojic, Simona Amodeo and Torsten Ochsenreiter (2018). The translationally controlled tumor protein TCTP is involved in cell cycle progression and heat stress response in the bloodstream form of Trypanosoma brucei. Microbial Cell: 5(10): 460-468. doi: 10.15698/mic2018.10.652
© 2018 Jojic et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
The translationally controlled tumor protein TCTP, is a universally conserved protein that seems to be of essential function in all systems tested so far. TCTP is involved in a multitude of cellular functions including cell cycle control, cell division, apoptosis and many more. The mechanism of how TCTP is involved in most of these functions remains elusive. Here we describe that TCTP is a cytoplasmic protein involved in cell cycle regulation and heat stress response in the bloodstream form of Trypanosoma brucei.