Affiliations: 1 Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
2 Medical Biochemistry and Molecular Biology, Center for Molecular Signaling, PZMS, Saarland University, School of Medicine, 66421 Homburg, Germany.
Keywords:
mitochondria, cristae, membrane architecture, contact site, MICOS, F1Fo-ATP synthase, Mic10, respiration.
Corresponding Author(s):
Heike Rampelt, Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; heike.rampelt@biochemie.uni-freiburg.de
Martin van der Laan, Medical Biochemistry and Molecular Biology, Center for Molecular Signaling, PZMS, Saarland University, School of Medicine, 66421 Homburg, Germany; martin.van-der-laan@uks.eu
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Heike Rampelt and Martin van der Laan (2017). The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation. Microbial Cell 4(8): 236-239. doi: 10.15698/mic2017.08.583
© 2017 Rampelt and van der Laan. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
The Yin & Yang of Mitochondrial Architecture – Interplay of MICOS and F1Fo-ATP synthase in cristae formation
Authors:Heike Rampelt1 and Martin van der Laan2
doi: 10.15698/mic2017.08.583
Volume 4, pp. 236 to 239, published 07/08/2017.
1 Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
2 Medical Biochemistry and Molecular Biology, Center for Molecular Signaling, PZMS, Saarland University, School of Medicine, 66421 Homburg, Germany.
Keywords:
mitochondria, cristae, membrane architecture, contact site, MICOS, F1Fo-ATP synthase, Mic10, respiration.
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Heike Rampelt and Martin van der Laan (2017). The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation. Microbial Cell 4(8): 236-239. doi: 10.15698/mic2017.08.583
© 2017 Rampelt and van der Laan. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Oxidative phosphorylation takes place at specialized compartments of the inner mitochondrial membrane, the cristae. The elaborate ultrastructure of cristae membranes enables efficient chemi-osmotic coupling of respiratory chain and F1Fo-ATP synthase. Dynamic membrane remodeling allows mitochondria to adapt to changing physiological requirements. The mitochondrial contact site and cristae organizing system (MICOS) and the oligomeric ATP synthase have been known to govern distinct features of cristae architecture. A new study [cite]10.15698/mic2017.08.585[/cite] on the crosstalk between these two machineries now sheds light on the mechanisms of cristae formation and maintenance.