The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes

January 27, 2023

By CRISPR/Cas9 knockout and biophysical analysis, we show here that the invariant surface glycoprotein 75 directly binds the the century-old drug suramin and mediates uptake of additional naphthol-related compounds, making this glycoprotein a conduit for entry of at least one structural class of trypanocidal compounds.

The long and winding road of reverse genetics in Trypanosoma cruzi

August 5, 2021

This Editorial provides a brief historic overview that highlights the strengths and weaknesses of the molecular strategies that have been developed to genetically modify Trypanosoma cruzi, emphasizing the future directions of the field.

The cytosolic glyoxalases of Plasmodium falciparum are dispensable during asexual blood-stage development

November 20, 2017

In this study the authors demonstrate that, PfGlo1 and PfcGlo2 are dispensable during asexual blood-stage development while the loss of PfcGlo2 may induce the formation of transmissible gametocytes. These combined data show that PfGlo1 and PfcGlo2 are most likely not suited as targets for selective drug development against the malaria parasite Plasmodium falciparum.