A yeast model for the mechanism of the Epstein-Barr virus immune evasion identifies a new therapeutic target to interfere with the virus stealthiness

August 31, 2017

This article comments on a publication by Lista et al. (Nature Communications, 2017) that uncovered the role of the host cell nucleolin (NCL) in EBNA1 self-limitation of expression via a direct interaction of this protein with G-quadruplexes (G4) formed in GAr-encoding sequence of EBNA1 mRNA.