yeast – Page 8 – Microbial Cell

Fatal attraction in glycolysis: how Saccharomyces cerevisiae manages sudden transitions to high glucose

February 20, 2014

This article comments on work published by van Heerden et al. (Science, 2014), which demonstrates that the startup of glycolysis exhibits two dynamic fates: a proper, functional, steady state or the imbalanced state described above. Both states are stable, attracting states, and the probability distribution of initial states determines the fate of a yeast cell exposed to glucose.

A novel mechanism involved in the coupling of mitochondrial biogenesis to oxidative phosphorylation

January 5, 2014

This article comments on a study by Ostojić et al. (Cell Metabolism, 2013), which has uncovered a regulatory loop by which the biogenesis of a major enzyme of the OXPHOS pathway, the respiratory complex III, is coupled to the energy producing activity of the mitochondria.

Early manifestations of replicative aging in the yeast Saccharomyces cerevisiae.

January 4, 2014

The data preseted herein suggest that retrograde signaling starts to malfunction in relatively young cells, leading to accumulation of heterogeneous mitochondria within one cell. The latter may further contribute to a decline in stress resistances.