Commentary, In the pit

The emerging role of complex modifications of tRNALysUUU in signaling pathways

Patrick C. Thiaville1,2,3,4 and Valérie de Crécy-Lagard2,4

This comment discusses the article "Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling" by Scheidt et al (Microbial Cell, 2014).

Metabolic pathways further increase the complexity of cell size control in budding yeast

Jorrit M. Enserink

This article comments on work published by Soma et al. (Microbial Cell, 2014), which teased apart the effect of metabolism and growth rate on setting of critical cell size in Saccharomyces cerevisiae.

Only functional localization is faithful localization

Roland Lill1,2,3

This article comments on work published by Peleh et al. (Microbial Cell 2014), which analyzes the localization of Dre2 in Saccharomyces cerevisiae.

Metabolites in aging and autophagy

Sabrina Schroeder1,#, Andreas Zimmermann1,#, Didac Carmona-Gutierrez1, Tobias Eisenberg1, Christoph Ruckenstuhl1, Aleksandra Andryushkova1, Tobias Pendl1, Alexandra Harger1,2 and Frank Madeo1

This article analyzes the implications of specific metabolites in aging and autophagy with special emphasis on polyamine metabolism.

One cell, one love: a journal for microbial research

Didac Carmona-Gutierrez1, Guido Kroemer2-6 and Frank Madeo1

In this inaugural article of Microbial Cell, we highlight the importance of microbial research in general and the journal's intention to serve as a publishing forum that supports and enfolds the scientific diversity in this area as it provides a unique, high-quality and universally accessible source of information and inspiration.

What’s the role of autophagy in trypanosomes?

Katherine Figarella1 and Néstor L. Uzcátegui1,2

This article comments on Proto et al. (Microbial Cell, 2014), who report first insights into the molecular mechanism of autophagy in African trypanosomes by generating reporter bloodstream form cell lines.

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In the beginning was the word: How terminology drives our understanding of endosymbiotic organelles

January 21, 2019

This In the Pit article argues that the naming conventions for biological entities influence research perspectives and methodologies, advocating for mitochondria and plastids to be classified and named as bacteria due to their endosymbiotic origins, with potential implications for our understanding of bacterial prevalence, definitions of the microbiome and multicellularity, and the concept of endosymbiotic domestication.

What’s in a name? How organelles of endosymbiotic origin can be distinguished from endosymbionts

January 21, 2019

This In the Pit article suggests redefining the relationship between hosts and endosymbionts, like mitochondria and plastids, as a single species based on "sexual symbiont integration," the loss of independent speciation, and congruence in genetic recombination and population sizes, rather than solely on historic classifications or structural properties.