Special Issue: The Human Microbiome in Health and Disease

The human microbiome is a diverse consortium of bacteria, archaea, fungi, protozoa, and viruses that inhabit many parts of the human body. These consortia have been implicated in a range of vital physiological processes including energy homeostasis, metabolism, gut epithelial health, immunologic activity and neurobehavioral development. This Special Issue contains articles describing microbiota of different regions, including the oral cavity, the gut and the vagina as well as their implications on cancer, immunity and the brain. Moreover, treatment options are discussed such as microbiome transplantation or probotic therapy. In addition, articles about special microbiota, including the human virome or the infant microbiome are also part of this Special Issue.

Gut microbial metabolites in depression: understanding the biochemical mechanisms

Giorgia Caspani, Sidney Kennedy, Jane A. Foster and Jonathan Swann

2019 | 10.15698/mic2019.10.693 | Reviews

This article shows how the gut microbiota contributes to the pathophysiology of depression and examines the mechanisms by which microbially-derived molecules may influence depressive behavior, highlighting the potential of dietary interventions as novel therapeutic strategies.

Beyond cells – The virome in the human holobiont

Rodrigo García-López, Vicente Pérez-Brocal and Andrés Moya

2019 | 10.15698/mic2019.09.689 | Reviews

This article provides an overview of viromics—viral metagenomics—and its evolution, highlighting the complexity and dynamic nature of viruses beyond their traditional view as pathogens. It acknowledges the technological advancements in molecular biology and sequencing that have allowed the field to grow, while also noting that viromic research still faces significant challenges and is not as developed as bacterial metagenomics. The review underscores the importance of viruses in various ecosystems, their role in shaping the genetic landscape, and their potential impact, and looks forward to future directions in viromic research.

The influence of the microbiota on immune development, chronic inflammation, and cancer in the context of aging

Taylor N. Tibbs, Lacey R. Lopez and Janelle C. Arthur

2019 | 10.15698/mic2019.08.685 | Reviews

This article shows that the microbiota is crucial for immune system development and that its relationship with the immune system during aging and the pathogenesis of age-related diseases, including cancer, needs further research to inform disease treatment and prevention.

Forty-five-year evolution of probiotic therapy

Scarlett Puebla-Barragan and Gregor Reid

2019 | 10.15698/mic2019.04.673 | Reviews

The field of probiotics has greatly expanded over the past 45 years, driven by the need for safer alternatives to drugs, interest in natural microbial products, and clinical proof of effectiveness, with scientific formulations increasingly defining the market and promising applications for various health areas expected in the future.