The human microbiome is a diverse consortium of bacteria, archaea, fungi, protozoa, and viruses that inhabit many parts of the human body. These consortia have been implicated in a range of vital physiological processes including energy homeostasis, metabolism, gut epithelial health, immunologic activity and neurobehavioral development. This Special Issue contains articles describing microbiota of different regions, including the oral cavity, the gut and the vagina as well as their implications on cancer, immunity and the brain. Moreover, treatment options are discussed such as microbiome transplantation or probotic therapy. In addition, articles about special microbiota, including the human virome or the infant microbiome are also part of this Special Issue.
Gut microbial metabolites in depression: understanding the biochemical mechanisms
Giorgia Caspani, Sidney Kennedy, Jane A. Foster and Jonathan Swann
2019 | 10.15698/mic2019.10.693 | Reviews
This article shows how the gut microbiota contributes to the pathophysiology of depression and examines the mechanisms by which microbially-derived molecules may influence depressive behavior, highlighting the potential of dietary interventions as novel therapeutic strategies.
The influence of the microbiota on immune development, chronic inflammation, and cancer in the context of aging
Taylor N. Tibbs, Lacey R. Lopez and Janelle C. Arthur
2019 | 10.15698/mic2019.08.685 | Reviews
This article shows that the microbiota is crucial for immune system development and that its relationship with the immune system during aging and the pathogenesis of age-related diseases, including cancer, needs further research to inform disease treatment and prevention.
Forty-five-year evolution of probiotic therapy
Scarlett Puebla-Barragan and Gregor Reid
2019 | 10.15698/mic2019.04.673 | Reviews
The field of probiotics has greatly expanded over the past 45 years, driven by the need for safer alternatives to drugs, interest in natural microbial products, and clinical proof of effectiveness, with scientific formulations increasingly defining the market and promising applications for various health areas expected in the future.