Clonal spread and environmental persistence of carbapenem-resistant high-risk Pseudomonas aeruginosa in critical-care units of a Chilean national referral center for burn and trauma patients (2022)
This study highlight the circulation of high-risk P. aeruginosa clones in Chile and underscore the importance of molecular epidemiology in guiding infection control, optimizing antimicrobial therapy, and mitigating the clinical and economic burden of CRPA.
The transcriptome of dendritic cells redraws the boundaries between pathogenicity and commensalism in yeast
Our immune system meets many fungi, but reacts strongly to only a few. The comparison of key fungal species showed that responses differ mainly in timing and not just genes, highlighting the need to rethink what makes fungi harmful vs. harmless.
Yippee-like protein Moh1 links gene expression to metabolism and selective stress resistance in Saccharomyces cerevisiae
This study demonstrates that the conserved yeast protein Moh1 links metabolism, gene expression, and cell structure, thereby altering cell envelope permeability and leading to selective stress responses.
Fungistatic effect of sorbic acid on yeast cells via translational repression involving eIF2α phosphorylation and formation of Ded1- and eIF2B-granules
The findings of this study provide new insights into the physiological effects of sorbic acid on yeast cells, specifically regarding the regulation of translation-related factors.
Occlusal types shape oral microbiome stomatotypes and metabolic landscapes: A multi-omics perspective on host-microbe interaction
This study reveals how occlusal types shape oral microbiome “stomatotypes” and metabolic profiles in adolescents. It offers fresh insights that host anatomy drives microecology which may be associated with personalized oral health.
Transcriptomic response to different heme sources in Trypanosoma cruzi epimastigotes
Tevere et al.This study uncovers how the Chagas disease parasite adapts to changes in heme, an essential molecule for its survival, providing transcriptional clues to heme metabolism and identifying a previously unreported heme-binding protein in T. cruzi.
Sir2 regulates selective autophagy in stationary-phase yeast cells
Ryu et al.This study establishes Sir2 as a previously unrecognized regulator of selective autophagy during the stationary phase and highlight how cells dynamically control organelle degradation.
Molecular signature of the imprintosome complex at the mating-type locus in fission yeast
Raimondi et al.Genetic and molecular studies have indicated that an epigenetic imprint at mat1, the sexual locus of fission yeast, initiates mating type switching. Here, Raimondi et al. characterized the recruitment of early players of mating type switching at the mat1 region and suggest a nucleoprotein protective structure defined as imprintosome.
A novel system to monitor mitochondrial translation in yeast
Suhm et al.In this study Suhm et al. present a novel system to monitor mitochondrial translation by detection of mitochondrial GFP-translation through fluorescence microscopy and flow cytometry in functional mitochondria. This novel tool allows the investigation of the function and regulation of mitochondrial translation during stress signaling, aging and mitochondrial biogenesis.
Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes
Hayes et al.Fat storage-inducing transmembrane (FIT or FITM) proteins have been implicated in the partitioning of triacylglycerol to lipid droplets and the budding of lipid droplets from the ER. Saccharomyces cerevisiae has two FITM homologues and the presented results suggest that Scs3p and Yft2p as well as FITMs in general are lipid phosphatase/phosphotransferase (LPT) enzymes involved in an as yet unknown critical step in phospholipid metabolism.
Yeast quiescence exit swiftness is influenced by cell volume and chronological age
Laporte et al.Quiescence exit swiftness is crucial not only for micro-organisms in competition for an environmental niche, such as yeast, but also for the maintenance of tissue homeostasis in multicellular species. Here, Laporte et al. explore the effect of replicative and chronological age on Saccharomyces cerevisiae quiescence exit efficiency. Overall, their data illustrate that the quiescent state is a continuum evolving with time, early and deep quiescence being distinguishable by the cell’s proficiency to re-enter the proliferation cycle.
A versatile plasmid system for reconstitution and analysis of mammalian ubiquitination cascades in yeast
Avagliano Trezza et al.In this article Avagliano Trezza et al. describe a versatile vector system that allows the reconstitution of specific ubiquitination cascades in the model eukaryote Saccharomyces cerevisae (baker’s yeast) that provides a versatile tool to study complex post-translational modifications in a cellular setting.
Alcohols enhance the rate of acetic acid diffusion in S. cerevisiae : biophysical mechanisms and implications for acetic acid tolerance
Lindahl et al.Microbial cell factories with the ability to maintain high productivity in the presence of weak organic acids, such as acetic acid, are required in many industrial processes. This study demonstrates that the rate of acetic acid diffusion can be strongly affected by compounds that partition into the cell membrane, and highlights the need for considering interaction effects between compounds in the design of microbial processes.
A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis
Hagihara et al.Fingolimod hydrochloride (FTY720) is an immune modulator for multiple sclerosis that also induces cancer cell apoptosis through reactive oxygen species generation, with a new study using fission yeast uncovering a gene network related to ROS homeostasis as a possible mechanism of FTY720’s toxicity.
Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm
Rivera-Palomino and TheissProhibitins are emerging as central host hubs exploited by bacteria and viruses to rewire signaling and mitochondrial dynamics. The current review discusses Prohibitins in host-pathogen interplay and their potential as novel anti-infective targets.
Outer membrane vesicles in Vibrio species: Roles in biofilm formation and pathogenesis
Shambhavi and SinghThis review explores current knowledge on outer membrane vesicles (OMVs) in Vibrio species, highlighting their roles in pathogenesis, host interaction, and marine ecology; and identifies major knowledge gaps, outlining key methodological challenges and future prospects for OMV-based applications.
The mechanism of Tat-dependent protein translocation
Brüser and SandersThis review integrates mechanistically relevant biochemical, molecular, and structural studies on Tat-dependent translocation of folded proteins into an in its molecular detail new comprehensive explanation of how the Tat system mediates protein transport.
From the gut to the lungs: The role of gut microbiota in chronic obstructive pulmonary disease and related research progress
Yang et al.This article provides new ideas and directions for the basic research and clinical practice of COPD by comprehensively sorting out the association between gut microbiota and COPD.
Protein arginine methyltransferases in protozoan parasites: a new path for antiparasitic chemotherapy?
Campagnaro et al.This review discusses the activity and the relevance of arginine methyltransferases for the survival of pathogenic kinetoplastids, apicomplexans and amoebas, and how these enzymes could be exploited as drug targets.
Gut microbiota and ankylosing spondylitis: current insights and future challenges
Lobiuc et al.This review explores the growing role of gut microbiota in AS and its potential to reshape targeted treatment strategies and facilitate development of adjunct therapies to address disease onset and progression.
Advancements in vaginal microbiota, Trichomonas vaginalis, and vaginal cell interactions: Insights from co-culture assays
Cardoso and TascaThis review updates co-culture and co-incubation techniques for studying interactions of Lactobacillus spp., representing a pre-dominant member of the healthy vaginal microbiota; Candida spp., the most abundant yeast in the vagina, and T. vaginalis, responsible for the most widespread nonviral STI worldwide.
Influence of cervicovaginal microbiota on Chlamydia trachomatis infection dynamics
Hand et al.This review examines the complex interplay between the cervicovaginal microbiome, C. trachomatis infection, and host immune responses, highlighting the role of metabolites such as short-chain and long-chain fatty acids, indole, and iron in modulating pathogen survival and host defenses.
Unveiling the molecular architecture of the mitochondrial respiratory chain of Acanthamoeba castellanii
Scheckhuber et al.This review provides a comprehensive overview of the mitochondrial res-piratory chain in A. castellanii, focusing on the key alternative components involved in oxidative phosphorylation and their roles in energy metabolism, stress response, and adaptation to various conditions.
Targeting GATA transcription factors – a novel strategy for anti-aging interventions?
Zimmermann et al.This article comments on work published by Carmona-Gutierrez et al. (Nat Commun., 2019), which identified a natural compound, 4,4′-dimethoxychalcone, inducing autophagy and prolonging lifespan in different organisms through a mechanism that involves GATA transcription factors.
In the beginning was the word: How terminology drives our understanding of endosymbiotic organelles
OborníkThis In the Pit article argues that the naming conventions for biological entities influence research perspectives and methodologies, advocating for mitochondria and plastids to be classified and named as bacteria due to their endosymbiotic origins, with potential implications for our understanding of bacterial prevalence, definitions of the microbiome and multicellularity, and the concept of endosymbiotic domestication.
What’s in a name? How organelles of endosymbiotic origin can be distinguished from endosymbionts
GruberThis In the Pit article suggests redefining the relationship between hosts and endosymbionts, like mitochondria and plastids, as a single species based on “sexual symbiont integration,” the loss of independent speciation, and congruence in genetic recombination and population sizes, rather than solely on historic classifications or structural properties.
Microbial wars: competition in ecological niches and within the microbiome
Bauer et al.In this Editorial Bauer et al. provide a brief overview on microbial competition and discuss some of its roles and consequences that directly affect humans.
Exploring the mechanism of amebic trogocytosis: the role of amebic lysosomes
Gilmartin and PetriIn this article, the authors comment on the study “Inhibition of Amebic Lysosomal Acidification Blocks Amebic Trogocytosis and Cell Killing” by Gilmartin et al. (MBio, 2017), discussing the the role of amebic lysosomes in Trogocytosis, the intracellular transfer of fragments of cell material.
Uncovering the hidden: complexity and strategies for diagnosing latent tuberculosis
Flores-ValdezThis editorial postulates that advanced proteomic and transcriptomic techniques are evolving and may enhance the detection of latent tuberculosis, thereby distinguishing true M. tuberculosis infections from other conditions, which is vital for controlling potential reactivation and transmission.
The Yin & Yang of Mitochondrial Architecture – Interplay of MICOS and F1Fo-ATP synthase in cristae formation
Rampelt and van der LaanThis Editorial posits that mitochondrial cristae architecture is shaped by the interplay of MICOS and ATP synthase, with a recent study illuminating their roles in cristae formation and maintenance.
When a ribosomal protein grows up – the ribosome assembly path of Rps3
Brigitte PertschyThis article comments on two papers by Mitterer et al., which followed yeast protein Rps3, highlighting the sophisticated mechanisms for protein protection, nuclear transport, and integration into pre-ribosomal particles for final assembly with 40S subunits.
Can’t find what you’re looking for?
You can browse all our issues and published articles here.
FAQs
Peer-reviewed, open-access research using unicellular organisms (and multicellular microorganisms) to understand cellular responses and human disease.
The journal (founded in 2014) is led by its Editors-in-Chief Frank Madeo, Didac Carmona-Gutierrez, and Guido Kroemer
Microbial Cell has been publishing original scientific literature since 2014, and from the very beginning has been managed by active scientists through an independent Publishing House (Shared science Publishers). The journal was conceived as a platform to acknowledge the importance of unicellular organisms, both as model systems as well as in the biological context of human health and disease.
Ever since, Microbial Cell has very positively developed and strongly grown into a respected journal in the unicellular research community and even beyond. This scientific impact is reflected in the yearly number of citations obtained by articles published in Microbial Cell, as recorded by the Web of Science (Clarivate, formerly Thomson/Reuters):
The scientific impact of Microbial Cell is also mirrored in a series of milestones:
2015: Microbial Cell is included in the Emerging Sources Citation Index (ESCI), a selection of developing journals drafted by Clarivate Analytics based on the candidate’s publishing standards, quality, editorial content, and citation data. Note: As an ESCI-selected journal, Microbial Cell is currently being evaluated in a rigorous and long process to determine an inclusion in the Science Citation Index Expanded (SCIE), which allows the official calculation of Clarivate Analytics’ impact factor.
2016: Microbial Cell is awarded the so-called DOAJ Seal by the selective Directory of Open Access Journals (DOAJ). The DOAJ Seal is an exclusive mark of certification for open access journals granted by DOAJ to journals that adhere to outstanding best practice and achieve an extra high and clear commitment to open access and high publishing standards.
2017: Microbial Cell is included in Pubmed Central (PMC), allowing the archiving of all the journal’s articles in PMC and PubMed.
2019: Microbial Cell is indexed in the prestigious abstract and citation database Scopus after a thorough selection process. This also means that Microbial Cell obtains, for the first time, an official Scopus CiteScore as well as an official journal ranking in the Scimago Journal and Country Ranking.
2022: Microbial Cell’s CiteScore reaches a value of 7.2 for the year 2021, positioning Microbial Cell among the top microbiology journals (previously available CiteScores: 2019: 5.4; 2020: 5.1).
2022: Microbial Cell is indexed in the highly selective Science Citation Index Expanded™, which covers approx. 9,500 of the world’s most impactful journals across 178 scientific disciplines. In their journal selection and curation process, Clarivate´s editors apply 24 ‘quality’ criteria and four ‘impact’ criteria to select the most influential journals in their respective fields. This selection is also a pre-requisite for inclusion in the JCR, which features the impact factor.
2022: Microbial Cell is listed in the Journal Citation Reports™ (JCR), and obtains its first official Journal Impact Factor™ (JIF) for the year 2021: 5.316.Check Article Types and Manuscript Preparation guidelines. Submit online via Scholastica.
Sulfur dioxide resistance in Saccharomyces cerevisiae: beyond SSU1
García-Ríos and GuillamónThis article discusses the importance of understanding sulfite resistance in Saccharomyces cerevisiae due to its use in winemaking and the potential role of the transcription factor Com2. While the SSU1 gene and its activity have been correlated with sulfite tolerance, the work by Lage et al. (2019) indicates that Com2 might control a large percentage of the genes activated by SO2 and contribute to the yeast’s protective response, offering new insights into the molecular factors influencing this oenological trait.