Commentary, News and thoughts

The long and winding road of reverse genetics in Trypanosoma cruzi

Miguel A. Chiurillo1 and Noelia Lander1

This Editorial provides a brief historic overview that highlights the strengths and weaknesses of the molecular strategies that have been developed to genetically modify Trypanosoma cruzi, emphasizing the future directions of the field.

Means of intracellular communication: touching, kissing, fusing

Anne Spang1

This work highlights different aspects of communication between organelles, including the importance of organellar contact sites.

Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled

Katherine Figarella1

This Editorial addresses the meningo-encephalitic stage of Trypanosoma brucei infection and the resultig neuropathogenesis as well as the impact that the application of tools developed in the last years in the field of neuroscience will have on the study of neglected tropical diseases.

Lichens – growing greenhouses en miniature

Martin Grube1

This commentary article provides an overview on different aspects of lichen biology and the remarkable symbiotic association between fungi and algae.

Regulation of the mitochondrial permeability transition pore and its effects on aging

Damiano Pellegrino-Coppola1

Aging is linked to mitochondrial function, with the mitochondrial permeability transition pore (mPTP) playing a key role. Yeast is a useful model for studying how mPTP affects cell survival, aging, and related diseases.

Fungal infections in humans: the silent crisis

Katharina Kainz1, Maria A. Bauer1, Frank Madeo1-3 and Didac Carmona-Gutierrez1

This article highlights the growing global threat of fungal infections - exacerbated by rising drug resistance and medical practices - and emphasizes the urgent need for intensified research to develop more effective antifungal strategies.

Digesting the crisis: autophagy and coronaviruses

Didac Carmona-Gutierrez1, Maria A. Bauer1, Andreas Zimmermann1,2, Katharina Kainz1,
Sebastian J. Hofer1, Guido Kroemer3-7 and Frank Madeo1,2,8

This article reviews the multifaceted role of autophagy in antiviral defense and highlights how coronaviruses, including SARS-CoV-2, interact with this pathway, raising the possibility that targeting autophagy could offer novel therapeutic strategies against COVID-19.

Raman-based sorting of microbial cells to link functions to their genes

Kang Soo Lee1, Michael Wagner2,3 and Roman Stocker1

In this article, the authors comment on the study "An automated Raman-based platform for the sorting of live cells by functional properties" by Lee et al. (Nat Microbiol, 2019), which presents a high-throughput optofluidic platform that integrates Raman microspectroscopy and microfluidics to accurately link microbial phenotypes to genotypes within complex communities, enabling efficient functional sorting and analysis of microbiome members.

Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death?

Jie Gao1, Sabrina Chau1 and Marc D. Meneghini1

This article relates to the study "Meiotic viral attenuation through an ancestral apoptotic pathway" by Gao et al. (Proc Natl Acad Sci, 2019), which shows that programmed cell death may have evolved as a viral defence mechanism, as demonstrated by yeast studies showing that the mitochondrial nuclease Nuc1 translocates to the cytosol during meiosis to attenuate dsRNA viruses, linking viral control to meiotic cell death processes.

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Metabolic pathways further increase the complexity of cell size control in budding yeast

August 22, 2014

This article comments on work published by Soma et al. (Microbial Cell, 2014), which teased apart the effect of metabolism and growth rate on setting of critical cell size in Saccharomyces cerevisiae.

Only functional localization is faithful localization

April 7, 2014

This article comments on work published by Peleh et al. (Microbial Cell 2014), which analyzes the localization of Dre2 in Saccharomyces cerevisiae.

What’s the role of autophagy in trypanosomes?

January 4, 2014

This article comments on Proto et al. (Microbial Cell, 2014), who report first insights into the molecular mechanism of autophagy in African trypanosomes by generating reporter bloodstream form cell lines.

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