Publications
Genome-wide studies of telomere biology in budding yeast
March 1, 2014
In the last decade, technical advances have allowed carrying out systematic genome-wide screens for mutants affecting various aspects of telomere biology. In this review we summarize these efforts, and the insights that this Systems Biology approach has produced so far.
Mnemons: encoding memory by protein super-assembly
February 25, 2014
This article comments on work published by Caudron and Barral (Cell, 2013), which proposes that polyQ- and polyN-based elements, termed mnemons, act as cellular memory devices to encode previous environmental conditions.
Intersubunit communications within KaiC hexamers contribute the robust rhythmicity of the cyanobacterial circadian clock
January 29, 2014
This article comments on work published by Kitayama et al. (Nat Comm, 2013), which suggests that intersubunit communication precisely synchronizes KaiC subunits to avoid dephasing, and contributes to the robustness of circadian rhythms in cyanobacteria.
Mitochondrial protein import under kinase surveillance
January 29, 2014
This article summarizes recent discoveries in the yeast Saccharomyces cerevisiae model system that point towards a vital role of reversible phosphorylation in regulation of mitochondrial protein import.
Building a flagellum in biological outer space
January 25, 2014
This article comments on work published by Evans et al. (Nature, 2013), which presents a simple and elegant transit mechanism in which growth is powered by the subunits themselves as they link head-to-tail in a chain that is pulled through the length of the growing structure to the tip. This new mechanism answers an old question and may have resonance in other assembly processes.
Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death
January 15, 2014
This work suggests that deleting AIF1 but not YCA1/MCA1 protects S. cerevisiae and Candida albicans from caspofungin-induced cell death. This is not only the first time that AIF1 has been specifically tied to cell death in Candida but also the first time that caspofungin resistance has been linked to the cell death machinery in yeast.
A novel mechanism involved in the coupling of mitochondrial biogenesis to oxidative phosphorylation
January 5, 2014
This article comments on a study by Ostojić et al. (Cell Metabolism, 2013), which has uncovered a regulatory loop by which the biogenesis of a major enzyme of the OXPHOS pathway, the respiratory complex III, is coupled to the energy producing activity of the mitochondria.
Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells
January 5, 2014
Overall, this article shows that the TORC1-Sch9p axis is deregulated in Isc1p-deficient Saccharomyces cerevisiae cells, contributing to mitochondrial dysfunction, enhanced oxidative stress sensitivity and premature aging of isc1Δ cells.
One cell, one love: a journal for microbial research
January 5, 2014
In this inaugural article of Microbial Cell, we highlight the importance of microbial research in general and the journal's intention to serve as a publishing forum that supports and enfolds the scientific diversity in this area as it provides a unique, high-quality and universally accessible source of information and inspiration.