A time-resolved high-throughput screening of fission yeast deletion mutants for oxidative stress resistance
By capturing dynamic trajectories rather than static outcomes, this study exposes hidden layers of growth under oxidative stress and identifies new genetic determinants of cellular resilience in fission yeast.
Clonal spread and environmental persistence of carbapenem-resistant high-risk Pseudomonas aeruginosa in critical-care units of a Chilean national referral center for burn and trauma patients (2022)
This study highlight the circulation of high-risk P. aeruginosa clones in Chile and underscore the importance of molecular epidemiology in guiding infection control, optimizing antimicrobial therapy, and mitigating the clinical and economic burden of CRPA.
The transcriptome of dendritic cells redraws the boundaries between pathogenicity and commensalism in yeast
Our immune system meets many fungi, but reacts strongly to only a few. The comparison of key fungal species showed that responses differ mainly in timing and not just genes, highlighting the need to rethink what makes fungi harmful vs. harmless.
Yippee-like protein Moh1 links gene expression to metabolism and selective stress resistance in Saccharomyces cerevisiae
This study demonstrates that the conserved yeast protein Moh1 links metabolism, gene expression, and cell structure, thereby altering cell envelope permeability and leading to selective stress responses.
Fungistatic effect of sorbic acid on yeast cells via translational repression involving eIF2α phosphorylation and formation of Ded1- and eIF2B-granules
The findings of this study provide new insights into the physiological effects of sorbic acid on yeast cells, specifically regarding the regulation of translation-related factors.
A time-resolved high-throughput screening of fission yeast deletion mutants for oxidative stress resistance
Pirsalehi et al.By capturing dynamic trajectories rather than static outcomes, this study exposes hidden layers of growth under oxidative stress and identifies new genetic determinants of cellular resilience in fission yeast.
Clonal spread and environmental persistence of carbapenem-resistant high-risk Pseudomonas aeruginosa in critical-care units of a Chilean national referral center for burn and trauma patients (2022)
Ibarra et al.This study highlight the circulation of high-risk P. aeruginosa clones in Chile and underscore the importance of molecular epidemiology in guiding infection control, optimizing antimicrobial therapy, and mitigating the clinical and economic burden of CRPA.
The transcriptome of dendritic cells redraws the boundaries between pathogenicity and commensalism in yeast
Rizzetto et al.Our immune system meets many fungi, but reacts strongly to only a few. The comparison of key fungal species showed that responses differ mainly in timing and not just genes, highlighting the need to rethink what makes fungi harmful vs. harmless.
Yippee-like protein Moh1 links gene expression to metabolism and selective stress resistance in Saccharomyces cerevisiae
Olgun et al.This study demonstrates that the conserved yeast protein Moh1 links metabolism, gene expression, and cell structure, thereby altering cell envelope permeability and leading to selective stress responses.
Fungistatic effect of sorbic acid on yeast cells via translational repression involving eIF2α phosphorylation and formation of Ded1- and eIF2B-granules
Yoshiyama et al.The findings of this study provide new insights into the physiological effects of sorbic acid on yeast cells, specifically regarding the regulation of translation-related factors.
Occlusal types shape oral microbiome stomatotypes and metabolic landscapes: A multi-omics perspective on host-microbe interaction
Duan et alThis study reveals how occlusal types shape oral microbiome “stomatotypes” and metabolic profiles in adolescents. It offers fresh insights that host anatomy drives microecology which may be associated with personalized oral health.
Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm
Rivera-Palomino and TheissProhibitins are emerging as central host hubs exploited by bacteria and viruses to rewire signaling and mitochondrial dynamics. The current review discusses Prohibitins in host-pathogen interplay and their potential as novel anti-infective targets.
Outer membrane vesicles in Vibrio species: Roles in biofilm formation and pathogenesis
Shambhavi and SinghThis review explores current knowledge on outer membrane vesicles (OMVs) in Vibrio species, highlighting their roles in pathogenesis, host interaction, and marine ecology; and identifies major knowledge gaps, outlining key methodological challenges and future prospects for OMV-based applications.
Genomic epidemiology of carbapenemase-producing Klebsiella pneumoniae circulating in a Chilean tertiary-care hospital (2021–2022): Molecular characterization, resistance-virulence convergence, and clinical associations
Araya et al.This study characterized carbapenem-resistant Kp (CR-Kp) strains isolated at the Hospital Clínico Universidad de Chile (HCUCH) 2021-2022 and explored associations with clinical characteristics.
Systematic analysis of nuclear gene function in respiratory growth and expression of the mitochondrial genome in S. cerevisiae
Stenger et al.Using yeast Saccharomyces cerevisiae, the authors identified 254 nuclear genes essential for respiratory growth and 12 required for viability without mtDNA. They also found 176 genes involved in mitochondrial protein synthesis and mtDNA maintenance, offering a comprehensive view of the processes supporting oxidative phosphorylation.
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
Ortega et al.This study reveals that conserved residues H3E73 and H4E53 in histones H3 and H4 play a crucial role in maintaining genome stability. Mutations at these sites increase recombinogenic DNA damage, likely due to replication-associated issues rather than transcriptional activity, highlighting their importance in DNA damage prevention and repair.
Sulforaphane alters the acidification of the yeast vacuole
Wilcox et al.This study identifies vacuolar pH regulation as a key factor in sulforaphane (SFN) sensitivity, showing that SFN-induced cell death in yeast – and potentially in human cancer cells – is linked to its ability to raise vacuolar or lysosomal pH.
Broad-spectrum antifungal activities and mechanism of drimane sesquiterpenoids
Edouarzin et al.This study identifies (-)-drimenol as a potent broad-spectrum antifungal agent effective against multiple pathogenic fungi, including drug-resistant strains, and reveals its mechanism of action involves disruption of fungal membranes and targeting Crk1-related pathways, with potential for structural optimization to enhance efficacy.
Stable and destabilized GFP reporters to monitor calcineurin activity in Saccharomyces cerevisiae
Diessl et al.This study introduces GFP-based transcriptional reporters driven by a calcineurin-dependent response element, enabling real-time monitoring of calcineurin activity in live yeast cells for studying stress responses, aging, and antifungal drug screening.
The euchromatic histone mark H3K36me3 preserves heterochromatin through sequestration of an acetyltransferase complex in fission yeast
Georgescu et al.This study reveals that the loss of heterochromatin silencing in Set2-deficient cells is due to unrestrained Mst2C activity, highlighting the need for spatially restricted chromatin-modifying enzymes to maintain distinct chromatin states.
Depletion of SNAP-23 and Syntaxin 4 alters lipid droplet homeostasis during Chlamydia infection
Monteiro-Brás et al.This study reveals that the plasma membrane SNARE proteins SNAP-23 and Syntaxin 4 are crucial for Chlamydia trachomatis development by regulating lipid droplet homeostasis and supporting the formation of infectious progeny within host cells.
Yeast can express and assemble bacterial secretins in the mitochondrial outer membrane
Natarajan et al.Secretins, essential components of bacterial secretion systems, can be expressed in yeast and show differential dependencies on mitochondrial import and assembly factors for membrane integration, suggesting diverse pathways for their assembly into the bacterial outer membrane.
Metabolic reprogramming of Salmonella infected macrophages and its modulation by iron availability and the mTOR pathway
Telser et al.This article shows that iron plays a critical role in both the immune response and metabolic reprogramming of macrophages during infection, influencing the TCA cycle and mTOR pathway, with implications for the growth of intracellular bacteria like Salmonella.
On the link between cell cycle and infection of the Alphaproteobacterium Brucella abortus
Michaël DegheltThis article comments on work published by Deghelt et al. (Nat Comm, 2014), which describe a cell cycle arrest and resume during the Brucella abortus trafficking in host cell, suggesting that like the model Alphaproteobacterium Caulobacter crescentus, these bacteria are able to block their cell cycle at the G1 phase when starvation is sensed.
Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs
Nir Fluman and Eitan BibiThis article comments on work published by Fluman et al. (Nat Comm, 2014), which describes the ability of bacterial multidrug transporters to move long molecules through the membrane in a processive manner.
The dual role of cyclin C connects stress regulated gene expression to mitochondrial dynamics
Randy Strich and Katrina F. CooperThis work summarizes the role cyclin C plays in regulating stress-responsive transcription in the budding yeast Saccharomyces cerevisiae, including mitochondrial fission and regulated cell death.
Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli
Daniel R. Brown et al.This article comments on work published by Brown et al. (Nat Comm, 2014), which showed that the transcription of relA is activated by NtrC during nitrogen starvation, revealing that in E. coli and related bacteria, NtrC functions in combinatorial stress and serves to couple two major stress responses, the Ntr response and stringent response.
The replication timing program in the hands of two HDACs
Kazumasa Yoshida et al.This article comments on work published by Yoshida et al. (Mol Cell, 2014), which performed a systematic analysis of the role of histone deacetylases (HDACs) in the regulation of origin activity in budding yeast, finding that the epigenetic regulation of repetitive sequences is a key determinant of the DNA replication program.
Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
Sam AlsfordThis article comments on work published by Alsford et al. (PLoS Pathogens, 2014), which identified a Trypanosoma brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action.
A novel role of centrin in flagellar motility: stabilizing an inner-arm dynein motor in the flagellar axoneme
Ziyin LiThis article comments on work published by Wei et al. (Nat Comm, 2014), which discovered that centrin maintains the stability of an inner-arm dynein in the flagellar axoneme in Trypanosoma brucei.
A non-proteolytic function of ubiquitin in transcription repression
Ada Ndoja and Tingting YaoThis article comments on work published by Ndoja et al. (Mol Cell, 2014), which demonstrates that monoubiquitination of some transcription activators can inhibit transcription by recruiting the AAA+ ATPase Cdc48 (also known in metazoans as p97 or VCP), which then extracts the ubiquitinated activator from DNA.
Mutagenesis by host antimicrobial peptides: insights into microbial evolution during chronic infections
Dominique H. Limoli and Daniel J. WozniakThis article comments on work published by Limoli et al. ((PLoS Pathogens, 2014), which provides evidence that at subinhibitory levels, AMPs promote mutations in bacterial DNA, which enhance bacterial survival.
The emerging role of complex modifications of tRNALysUUU in signaling pathways
Patrick C. Thiaville and Valérie de Crécy-LagardThis comment discusses the article “Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling” by Scheidt et al (Microbial Cell, 2014).
Only functional localization is faithful localization
Roland LillThis article comments on work published by Peleh et al. (Microbial Cell 2014), which analyzes the localization of Dre2 in Saccharomyces cerevisiae.
One cell, one love: a journal for microbial research
Didac Carmona-Gutierrez et al.In this inaugural article of Microbial Cell, we highlight the importance of microbial research in general and the journal’s intention to serve as a publishing forum that supports and enfolds the scientific diversity in this area as it provides a unique, high-quality and universally accessible source of information and inspiration.
What’s the role of autophagy in trypanosomes?
Katherine Figarella and Néstor L. UzcáteguiThis article comments on Proto et al. (Microbial Cell, 2014), who report first insights into the molecular mechanism of autophagy in African trypanosomes by generating reporter bloodstream form cell lines.
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Peer-reviewed, open-access research using unicellular organisms (and multicellular microorganisms) to understand cellular responses and human disease.
The journal (founded in 2014) is led by its Editors-in-Chief Frank Madeo, Didac Carmona-Gutierrez, and Guido Kroemer
Microbial Cell has been publishing original scientific literature since 2014, and from the very beginning has been managed by active scientists through an independent Publishing House (Shared science Publishers). The journal was conceived as a platform to acknowledge the importance of unicellular organisms, both as model systems as well as in the biological context of human health and disease.
Ever since, Microbial Cell has very positively developed and strongly grown into a respected journal in the unicellular research community and even beyond. This scientific impact is reflected in the yearly number of citations obtained by articles published in Microbial Cell, as recorded by the Web of Science (Clarivate, formerly Thomson/Reuters):
The scientific impact of Microbial Cell is also mirrored in a series of milestones:
2015: Microbial Cell is included in the Emerging Sources Citation Index (ESCI), a selection of developing journals drafted by Clarivate Analytics based on the candidate’s publishing standards, quality, editorial content, and citation data. Note: As an ESCI-selected journal, Microbial Cell is currently being evaluated in a rigorous and long process to determine an inclusion in the Science Citation Index Expanded (SCIE), which allows the official calculation of Clarivate Analytics’ impact factor.
2016: Microbial Cell is awarded the so-called DOAJ Seal by the selective Directory of Open Access Journals (DOAJ). The DOAJ Seal is an exclusive mark of certification for open access journals granted by DOAJ to journals that adhere to outstanding best practice and achieve an extra high and clear commitment to open access and high publishing standards.
2017: Microbial Cell is included in Pubmed Central (PMC), allowing the archiving of all the journal’s articles in PMC and PubMed.
2019: Microbial Cell is indexed in the prestigious abstract and citation database Scopus after a thorough selection process. This also means that Microbial Cell obtains, for the first time, an official Scopus CiteScore as well as an official journal ranking in the Scimago Journal and Country Ranking.
2022: Microbial Cell’s CiteScore reaches a value of 7.2 for the year 2021, positioning Microbial Cell among the top microbiology journals (previously available CiteScores: 2019: 5.4; 2020: 5.1).
2022: Microbial Cell is indexed in the highly selective Science Citation Index Expanded™, which covers approx. 9,500 of the world’s most impactful journals across 178 scientific disciplines. In their journal selection and curation process, Clarivate´s editors apply 24 ‘quality’ criteria and four ‘impact’ criteria to select the most influential journals in their respective fields. This selection is also a pre-requisite for inclusion in the JCR, which features the impact factor.
2022: Microbial Cell is listed in the Journal Citation Reports™ (JCR), and obtains its first official Journal Impact Factor™ (JIF) for the year 2021: 5.316.Check Article Types and Manuscript Preparation guidelines. Submit online via Scholastica.
Metabolic pathways further increase the complexity of cell size control in budding yeast
Jorrit M. EnserinkThis article comments on work published by Soma et al. (Microbial Cell, 2014), which teased apart the effect of metabolism and growth rate on setting of critical cell size in Saccharomyces cerevisiae.