Review, Reviews
The mechanism of Tat-dependent protein translocation
Thomas Brüser1,* and Carsten Sanders2,3,4
This review integrates mechanistically relevant biochemical, molecular, and structural studies on Tat-dependent translocation of folded proteins into an in its molecular detail new comprehensive explanation of how the Tat system mediates protein transport.
From the gut to the lungs: The role of gut microbiota in chronic obstructive pulmonary disease and related research progress
Simin Yang1,2, Shuting Zeng1,2, Yongan Deng1,2, Xiaodong Duan1,2, Chengkai Chen1,2, Luyun Sun2, Yongkang Qiao2 and Zunpeng Shu1,2
This article provides new ideas and directions for the basic research and clinical practice of COPD by comprehensively sorting out the association between gut microbiota and COPD.
Protein arginine methyltransferases in protozoan parasites: a new path for antiparasitic chemotherapy?
Gustavo D. Campagnaro1,* and Sébastien Pomel2
This review discusses the activity and the relevance of arginine methyltransferases for the survival of pathogenic kinetoplastids, apicomplexans and amoebas, and how these enzymes could be exploited as drug targets.
Gut microbiota and ankylosing spondylitis: current insights and future challenges
Andrei Lobiuc1, Liliana Groppa2, Lia Chislari2, Eugeniu Russu2,3, Marinela Homitchi2,3, Camelia Ciorescu2,3, Sevag Hamamah4, I. Codruta Bran1 and Mihai Covasa1
This review explores the growing role of gut microbiota in AS and its potential to reshape targeted treatment strategies and facilitate development of adjunct therapies to address disease onset and progression.
Advancements in vaginal microbiota, Trichomonas vaginalis, and vaginal cell interactions: Insights from co-culture assays
Fernanda Gomes Cardoso and Tiana Tasca
This review updates co-culture and co-incubation techniques for studying interactions of Lactobacillus spp., representing a pre-dominant member of the healthy vaginal microbiota; Candida spp., the most abundant yeast in the vagina, and T. vaginalis, responsible for the most widespread nonviral STI worldwide.
Influence of cervicovaginal microbiota on Chlamydia trachomatis infection dynamics
Emily Hand1, Indriati Hood-Pishchany1,2, Toni Darville1,2 and Catherine M. O’Connell2
This review examines the complex interplay between the cervicovaginal microbiome, C. trachomatis infection, and host immune responses, highlighting the role of metabolites such as short-chain and long-chain fatty acids, indole, and iron in modulating pathogen survival and host defenses.
Unveiling the molecular architecture of the mitochondrial respiratory chain of Acanthamoeba castellanii
Christian Q. Scheckhuber1, Sutherland K. Maciver2 and Alvaro de Obeso Fernandez del Valle1
This review provides a comprehensive overview of the mitochondrial res-piratory chain in A. castellanii, focusing on the key alternative components involved in oxidative phosphorylation and their roles in energy metabolism, stress response, and adaptation to various conditions.
Paving the way for new antimicrobial peptides through molecular de-extinction
Karen O. Osiro1, Abel Gil-Ley2, Fabiano C. Fernandes1,3, Kamila B. S. de Oliveira2, Cesar de la Fuente-Nunez4-7, Octavio L. Franco1,2
The advancement of artificial intelligence and molecular de-extinction offers a valuable opportunity not only to discover new antimicrobials but also to provide accurate in silico predictions, thereby shortening the path to addressing the global antibiotic resistance crisis.
Efflux pumps: gatekeepers of antibiotic resistance in Staphylococcus aureus biofilms
Shweta Sinha1, Shifu Aggarwal2,3 and Durg Vijai Singh1
This review aims to elucidate the complex relationship between efflux pumps, antibiotic resistance and biofilm formation in S. aureus with the aim to aid in the development of potential therapeutic targets for combating S. aureus infections, especially those associated with biofilms.
Diverse conditions support near-zero growth in yeast: Implications for the study of cell lifespan
August 20, 2019
This review discusses alternative cultivation methods for baker's yeast to study its chronological lifespan, with the aim of better understanding the ageing of non-dividing cells and their potential implications for the lifespan of multicellular eukaryotes such as humans.
Integrins in disguise – mechanosensors in Saccharomyces cerevisiae as functional integrin analogues
July 15, 2019
This article shows that although yeast lack integrin-like proteins, they possess WSC- and MID-type mechanosensors that functionally resemble integrins in animal cells, playing a role in sensing external mechanical stimuli and activating the conserved PKC1-SLT1 cell wall integrity pathway, with potential implications for understanding mechanosensing in yeast biology.
Laundry and textile hygiene in healthcare and beyond
July 1, 2019
This article shows that while institutional laundering is regulated to ensure hygiene, the trend towards energy-efficient washing at lower temperatures raises concerns about the antimicrobial efficacy of domestic laundering, with a focus on addressing microbial contamination in both clinical and home settings.
Yeast AP-1 like transcription factors (Yap) and stress response: a current overview
May 28, 2019
This review summarizes current understanding of the eight Yap transcription factors in Saccharomyces cerevisiae, detailing their activation by specific stress conditions and discussing their function and evolution across various fungal species.
The influence of the microbiota on immune development, chronic inflammation, and cancer in the context of aging
May 13, 2019
This article shows that the microbiota is crucial for immune system development and that its relationship with the immune system during aging and the pathogenesis of age-related diseases, including cancer, needs further research to inform disease treatment and prevention.
Ser/Thr protein phosphatases in fungi: structure, regulation and function
April 24, 2019
In this work we present the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regulation and the roles they play in the most diverse aspects of cell biology.
Forty-five-year evolution of probiotic therapy
April 2, 2019
The field of probiotics has greatly expanded over the past 45 years, driven by the need for safer alternatives to drugs, interest in natural microbial products, and clinical proof of effectiveness, with scientific formulations increasingly defining the market and promising applications for various health areas expected in the future.
Adaptive bacterial response to low level chlorhexidine exposure and its implications for hand hygiene
March 7, 2019
This article shows that bacteria can adapt to low levels of Chlorhexidine digluconate (CHG), resulting in increased tolerance and cross-resistance to other antimicrobials, suggesting caution in the widespread use of CHG to minimize avoidable selection pressure for resistance.
Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection
February 8, 2019
This review explores how Candida albicans and Candida glabrata, common fungal pathogens resistant to antifungal therapy, adapt and evolve within different environments, aiming to identify stable adaptive mechanisms as potential drug targets.