Review, Reviews
Bacterial maze runners reveal hidden diversity in chemotactic performance
M. Mehdi Salek1,#, Francesco Carrara1,#, Vicente Fernandez1 and Roman Stocker1
This article comments on work published by Salek et al. (Nat Commun, 2019), which combined microfluidic experiments with mathematical modeling to demonstrate that even in clonal populations, bacteria are individuals with different abilities to climb chemical gradients.
Laundry and textile hygiene in healthcare and beyond
Dirk P. Bockmühl1, Jan Schages1 and Laura Rehberg1
This article shows that while institutional laundering is regulated to ensure hygiene, the trend towards energy-efficient washing at lower temperatures raises concerns about the antimicrobial efficacy of domestic laundering, with a focus on addressing microbial contamination in both clinical and home settings.
Bacterial pathogens under high-tension: Staphylococcus aureus adhesion to von Willebrand factor is activated by force
Felipe Viela1, Pietro Speziale2,3, Giampiero Pietrocola2 and Yves F. Dufrêne1,4
This article comments on work published by Viela et al (mBio, 2019), which shows that the bacterial cell surface protein A to the large plasma glycoprotein von Willebrand factor interaction is tightly regulated by mechanical force.
Yeast AP-1 like transcription factors (Yap) and stress response: a current overview
Claudina Rodrigues-Pousada1, Frédéric Devaux2, Soraia M. Caetano1, Catarina Pimentel1, Sofia da Silva1, Ana Carolina Cordeiro1 and Catarina Amaral1
This review summarizes current understanding of the eight Yap transcription factors in Saccharomyces cerevisiae, detailing their activation by specific stress conditions and discussing their function and evolution across various fungal species.
Septin clearance from the division site triggers cytokinesis in budding yeast
Davide Tamborrini1 and Simonetta Piatti1
This article comments on work published by Tamborrini et al (Nat Commun., 2019), which shows that septin displacement during splitting is an essential prerequisite for contractile actomyosin ring constriction during mitosis.
The influence of the microbiota on immune development, chronic inflammation, and cancer in the context of aging
Taylor N. Tibbs1,#, Lacey R. Lopez1,#, and Janelle C. Arthur1,2,3
This article shows that the microbiota is crucial for immune system development and that its relationship with the immune system during aging and the pathogenesis of age-related diseases, including cancer, needs further research to inform disease treatment and prevention.
Ser/Thr protein phosphatases in fungi: structure, regulation and function
Joaquín Ariño1, Diego Velázquez1 and Antonio Casamayor1
In this work we present the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regulation and the roles they play in the most diverse aspects of cell biology.
Forty-five-year evolution of probiotic therapy
Scarlett Puebla-Barragan1,2 and Gregor Reid1,2
The field of probiotics has greatly expanded over the past 45 years, driven by the need for safer alternatives to drugs, interest in natural microbial products, and clinical proof of effectiveness, with scientific formulations increasingly defining the market and promising applications for various health areas expected in the future.
Adaptive bacterial response to low level chlorhexidine exposure and its implications for hand hygiene
March 7, 2019
This article shows that bacteria can adapt to low levels of Chlorhexidine digluconate (CHG), resulting in increased tolerance and cross-resistance to other antimicrobials, suggesting caution in the widespread use of CHG to minimize avoidable selection pressure for resistance.
Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection
February 8, 2019
This review explores how Candida albicans and Candida glabrata, common fungal pathogens resistant to antifungal therapy, adapt and evolve within different environments, aiming to identify stable adaptive mechanisms as potential drug targets.
The extracellular matrix of mycobacterial biofilms: could we shorten the treatment of mycobacterial infections?
January 18, 2019
The article discusses the challenges presented by biofilms formed by non-tuberculous mycobacteria (NTM) species, which can lead to persistent infections that are difficult to treat due to phenotypic drug tolerance. The role of various cell wall components in mycobacterial biofilm formation is outlined, with a particular focus on Mycobacterium tuberculosis.
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
January 7, 2019
DNA recombination, repair and mutagenesis assays are powerful tools but each comes with its particular advantages and limitations. Here the most commonly used assays are reviewed, discussed, and presented as the guidelines for future studies.
Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes
January 7, 2019
Mechanistic assays of DNA repair processes are a powerful tools but each comes with its particular advantages and limitations. Here the most commonly used assays are reviewed, discussed, and presented as the guidelines for future studies.
Pathways of host cell exit by intracellular pathogens
October 18, 2018
This review provides an overview of the diverse host cell exit strategies employed by intracellular-living bacterial, fungal, and protozoan pathogens, highlighting the commonalities and system-specific variations of these strategies, and discussing potential microbial molecules involved in host cell exit as targets for future intervention approaches.
Protective roles of ginseng against bacterial infection
September 19, 2018
This review highlights the antibacterial effects of ginseng against pathogenic bacterial infections, discussing its regulation of pathogenic factors and proposing the therapeutic potential of ginseng as a natural antibacterial drug to address antibiotic resistance and toxicity in the context of global public health challenges.
A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell’s mass degradation processes
September 18, 2018
This review summarizes the expanded roles of the Saccharomyces cerevisiae vacuolar proteases Pep4 and Prb1 in non-vacuolar activities outside of autophagy, such as programmed cell death, protection from harmful protein forms, and gene expression regulation. The potential implications of these findings for fungal biology and drug target discovery, including insights for mammalian cell studies, are highlighted, emphasizing the need for a deeper understanding of these molecular processes.
The biosynthesis of pyoverdines
August 28, 2018
This review provides an overview of pyoverdine biosynthesis, emphasizing the distinctive fluorophore shared by various pyoverdines derived from ferribactins and the role of periplasmic processes in the maturation and modification of these siderophores, critical for the growth and colonization of hosts by fluorescent pseudomonads.